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    Plekha5 pleckstrin homology domain containing, family A member 5 [ Mus musculus (house mouse) ]

    Gene ID: 109135, updated on 27-Jul-2021

    Summary

    Official Symbol
    Plekha5provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family A member 5provided by MGI
    Primary source
    MGI:MGI:1923802
    See related
    Ensembl:ENSMUSG00000030231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PE; AMH-C; Pepp2; Ayu21-; AMH-Cre; Ayu21-9; AI428202; AK129423; 2810431N21Rik; Gt(pU21)9Imeg; Tg(AMH-cre)1Flor
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E14 (RPKM 9.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plekha5 in Genome Data Viewer
    Location:
    6; 6 G2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (140369358..140542836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (140423639..140597110)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (140372620..140543427)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38917 Neighboring gene predicted gene 5051 Neighboring gene AE binding protein 2 Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1)  1 citation
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38455

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within reproductive system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 5
    Names
    Gt(Ayu21)9Imeg
    phosphoinositol 3-phosphate-binding protein-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144920.3NP_659169.3  pleckstrin homology domain-containing family A member 5

      Status: VALIDATED

      Source sequence(s)
      AK129423, CJ170110
      Consensus CDS
      CCDS39688.1
      UniProtKB/TrEMBL
      E9Q6H8, Q6ZPK1
      Related
      ENSMUSP00000084904.4, ENSMUST00000087622.6
      Conserved Domains (3) summary
      COG1196
      Location:623864
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      140369358..140542836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506863.3XP_006506926.1  pleckstrin homology domain-containing family A member 5 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:623864
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    2. XM_006506864.3XP_006506927.1  pleckstrin homology domain-containing family A member 5 isoform X8

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:632830
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    3. XM_006506869.3XP_006506932.1  pleckstrin homology domain-containing family A member 5 isoform X15

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:632830
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    4. XM_017321307.2XP_017176796.1  pleckstrin homology domain-containing family A member 5 isoform X2

      UniProtKB/TrEMBL
      E9Q6H8
      Conserved Domains (3) summary
      COG1196
      Location:623864
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    5. XM_017321309.2XP_017176798.1  pleckstrin homology domain-containing family A member 5 isoform X16

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:632830
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    6. XM_006506866.3XP_006506929.1  pleckstrin homology domain-containing family A member 5 isoform X10

      Conserved Domains (2) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    7. XM_006506861.3XP_006506924.1  pleckstrin homology domain-containing family A member 5 isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:623852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    8. XM_006506862.3XP_006506925.1  pleckstrin homology domain-containing family A member 5 isoform X6

      Conserved Domains (3) summary
      COG1196
      Location:623852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    9. XM_036165737.1XP_036021630.1  pleckstrin homology domain-containing family A member 5 isoform X18

      Conserved Domains (3) summary
      COG1196
      Location:623852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    10. XM_006506867.3XP_006506930.1  pleckstrin homology domain-containing family A member 5 isoform X11

      Conserved Domains (3) summary
      COG1196
      Location:623842
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    11. XM_030255075.2XP_030110935.1  pleckstrin homology domain-containing family A member 5 isoform X12

      Conserved Domains (3) summary
      COG1196
      Location:623842
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    12. XM_006506868.3XP_006506931.1  pleckstrin homology domain-containing family A member 5 isoform X13

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02169
      Location:639835
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00397
      Location:5988
      WW; WW domain
    13. XM_006506873.3XP_006506936.1  pleckstrin homology domain-containing family A member 5 isoform X21

      Conserved Domains (3) summary
      COG1196
      Location:638767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    14. XM_006506880.3XP_006506943.1  pleckstrin homology domain-containing family A member 5 isoform X30

      Conserved Domains (3) summary
      COG1196
      Location:638767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    15. XM_006506874.3XP_006506937.1  pleckstrin homology domain-containing family A member 5 isoform X22

      Conserved Domains (3) summary
      COG1196
      Location:641809
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    16. XM_006506878.3XP_006506941.1  pleckstrin homology domain-containing family A member 5 isoform X28

      Conserved Domains (3) summary
      COG1196
      Location:641809
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    17. XM_030255080.2XP_030110940.1  pleckstrin homology domain-containing family A member 5 isoform X31

      Conserved Domains (3) summary
      COG1196
      Location:641806
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    18. XM_006506883.3XP_006506946.1  pleckstrin homology domain-containing family A member 5 isoform X34

      Conserved Domains (3) summary
      COG1196
      Location:641806
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    19. XM_006506860.3XP_006506923.1  pleckstrin homology domain-containing family A member 5 isoform X3

      Conserved Domains (3) summary
      COG1196
      Location:617858
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    20. XM_036165734.1XP_036021627.1  pleckstrin homology domain-containing family A member 5 isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:617858
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    21. XM_036165736.1XP_036021629.1  pleckstrin homology domain-containing family A member 5 isoform X17

      Conserved Domains (3) summary
      COG1196
      Location:617858
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    22. XM_006506898.3XP_006506961.1  pleckstrin homology domain-containing family A member 5 isoform X7

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:626812
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    23. XM_036165738.1XP_036021631.1  pleckstrin homology domain-containing family A member 5 isoform X19

      Conserved Domains (3) summary
      COG1196
      Location:617846
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    24. XM_006506875.3XP_006506938.1  pleckstrin homology domain-containing family A member 5 isoform X25

      Related
      ENSMUSP00000145478.2, ENSMUST00000203517.3
      Conserved Domains (3) summary
      COG1196
      Location:617836
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    25. XM_036165739.1XP_036021632.1  pleckstrin homology domain-containing family A member 5 isoform X23

      Conserved Domains (3) summary
      COG1196
      Location:632761
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    26. XM_006506881.3XP_006506944.1  pleckstrin homology domain-containing family A member 5 isoform X32

      Conserved Domains (3) summary
      COG1196
      Location:632761
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    27. XM_030255078.2XP_030110938.1  pleckstrin homology domain-containing family A member 5 isoform X24

      Conserved Domains (3) summary
      COG1196
      Location:635803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    28. XM_036165741.1XP_036021634.1  pleckstrin homology domain-containing family A member 5 isoform X29

      Conserved Domains (3) summary
      COG1196
      Location:635803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    29. XM_006506882.4XP_006506945.1  pleckstrin homology domain-containing family A member 5 isoform X33

      Conserved Domains (3) summary
      COG1196
      Location:635800
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    30. XM_017321308.3XP_017176797.1  pleckstrin homology domain-containing family A member 5 isoform X9

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:632830
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    31. XM_030255077.2XP_030110937.1  pleckstrin homology domain-containing family A member 5 isoform X20

      Conserved Domains (3) summary
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:632830
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00397
      Location:5988
      WW; WW domain
    32. XM_036165735.1XP_036021628.1  pleckstrin homology domain-containing family A member 5 isoform X14

      Conserved Domains (3) summary
      COG1196
      Location:623842
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5988
      WW; WW domain
    33. XM_030255082.2XP_030110942.1  pleckstrin homology domain-containing family A member 5 isoform X36

      Conserved Domains (2) summary
      TIGR03185
      Location:402600
      DNA_S_dndD; DNA sulfur modification protein DndD
      cl17171
      Location:1544
      PH-like; Pleckstrin homology-like domain
    34. XM_030255083.2XP_030110943.1  pleckstrin homology domain-containing family A member 5 isoform X37

      Conserved Domains (2) summary
      COG1196
      Location:408537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:1544
      PH-like; Pleckstrin homology-like domain
    35. XM_036165742.1XP_036021635.1  pleckstrin homology domain-containing family A member 5 isoform X38

      Conserved Domains (2) summary
      COG1196
      Location:411576
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:1544
      PH-like; Pleckstrin homology-like domain
    36. XM_006506876.5XP_006506939.1  pleckstrin homology domain-containing family A member 5 isoform X26

      See identical proteins and their annotated locations for XP_006506939.1

      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR03185
      Location:523721
      DNA_S_dndD; DNA sulfur modification protein DndD
    37. XM_036165740.1XP_036021633.1  pleckstrin homology domain-containing family A member 5 isoform X27

      Conserved Domains (2) summary
      COG1196
      Location:514755
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    38. XM_006506885.3XP_006506948.1  pleckstrin homology domain-containing family A member 5 isoform X35

      Conserved Domains (2) summary
      TIGR03185
      Location:408606
      DNA_S_dndD; DNA sulfur modification protein DndD
      cl17171
      Location:1544
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_003956147.2 RNA Sequence

    2. XR_004942891.1 RNA Sequence

    3. XR_003956148.2 RNA Sequence

    4. XR_004942893.1 RNA Sequence

    5. XR_001785082.2 RNA Sequence

    6. XR_004942892.1 RNA Sequence

    7. XR_003956149.2 RNA Sequence

    8. XR_003956150.2 RNA Sequence

    9. XR_004942894.1 RNA Sequence

    10. XR_004942895.1 RNA Sequence

    11. XR_004942896.1 RNA Sequence

    12. XR_004942897.1 RNA Sequence

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