U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc22a28 solute carrier family 22, member 28 [ Mus musculus (house mouse) ]

    Gene ID: 434674, updated on 8-Feb-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Slc22a28provided by MGI
    Official Full Name
    solute carrier family 22, member 28provided by MGI
    Primary source
    MGI:MGI:3645714
    See related
    Ensembl:ENSMUSG00000063590 AllianceGenome:MGI:3645714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5631; EG434674
    Summary
    Predicted to enable anion:anion antiporter activity; short-chain fatty acid transmembrane transporter activity; and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in liver and metanephros. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25) and SLC22A9 (solute carrier family 22 member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver adult (RPKM 24.4) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    19 A; 19 5.39 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8039323..8109346, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8061958..8131982, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 27 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene calpastatin pseudogene Neighboring gene STARR-seq mESC enhancer starr_45475 Neighboring gene solute carrier family 22. member 29 Neighboring gene predicted gene, 41804 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    solute carrier family 22, member 28

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013820.3 → NP_001013842.2  solute carrier family 22, member 28

      See identical proteins and their annotated locations for NP_001013842.2

      Status: VALIDATED

      Source sequence(s)
      AK052719, BC139174
      Consensus CDS
      CCDS29534.1
      UniProtKB/TrEMBL
      B2RT89, Q8BWE8
      Related
      ENSMUSP00000067114.5, ENSMUST00000065651.5
      Conserved Domains (2) summary
      cd06174
      Location:151 → 516
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8039323..8109346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527179.3 → XP_006527242.1  solute carrier family 22, member 28 isoform X1

      UniProtKB/TrEMBL
      Q8BWE8
      Conserved Domains (1) summary
      cd17374
      Location:88 → 495
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    2. XM_011247277.2 → XP_011245579.1  solute carrier family 22, member 28 isoform X2

      UniProtKB/TrEMBL
      Q8BWE8
      Conserved Domains (1) summary
      cd17374
      Location:73 → 480
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    3. XM_011247278.2 → XP_011245580.1  solute carrier family 22, member 28 isoform X3

      UniProtKB/TrEMBL
      Q8BWE8
      Conserved Domains (1) summary
      cl28910
      Location:109 → 408
      MFS; Major Facilitator Superfamily

    4. XM_030250984.1 → XP_030106844.1  solute carrier family 22, member 28 isoform X6

      UniProtKB/TrEMBL
      Q810T7
      Conserved Domains (1) summary
      cl28910
      Location:109 → 428
      MFS; Major Facilitator Superfamily

    5. XM_011247279.1 → XP_011245581.1  solute carrier family 22, member 28 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:109 → 279
      MFS; Major Facilitator Superfamily

    6. XM_006527180.2 → XP_006527243.1  solute carrier family 22, member 28 isoform X5

      Conserved Domains (1) summary
      cl28910
      Location:109 → 275
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous