Ssh1 slingshot protein phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ssh1provided by MGI
Official Full Name: slingshot protein phosphatase 1provided by MGI
Primary source: MGI:MGI:2686240
See related: Ensembl:ENSMUSG00000042121 AllianceGenome:MGI:2686240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSH-1; Gm1394; Gm1395; SSH-1L
Summary: Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; modulation of chemical synaptic transmission; and positive regulation of AMPA glutamate receptor clustering. Predicted to act upstream of or within cellular response to ATP and regulation of cellular protein metabolic process. Predicted to be located in several cellular components, including cell leading edge; cytosol; and growth cone. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; eye epithelium; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human SSH1 (slingshot protein phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 10.8), spleen adult (RPKM 8.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.82 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114075155..114131864, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113937094..113993803, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.
Title: Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.
our work indicates that Ang II-dependent fibrotic gene expression and vascular remodeling, but not the Ang II-induced pressor response, are modulated by SSH1-mediated signaling pathways and SSH1 activity is protective against Ang II-induced remodeling in the vasculature
Title: The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo.
Caspase-11 targets cofilin via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase
Title: Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.
SSH1L knockdown, like S1P treatment, increased cardiomyocyte survival and preserved mitochondrial integrity after oxidative stress
Title: PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.
EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.
Title: EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase.
PDGF activates SSH1L in VSMC by a mechanism that involves Nox1-mediated oxidation of 14-3-3 and Ser-834 SSH1L auto-dephosphorylation.
Title: Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
Knockdown of SSH1 expression by RNA interference significantly suppressed stress fiber formation in C2C12 myoblast cells, indicating a role for SSH1 in stress fiber formation or stabilization in cells.
Title: Actin filaments-stabilizing and -bundling activities of cofilin-phosphatase Slingshot-1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235266

AW551225 (e-PCR)
- UniSTS:179229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to ATP	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase Slingshot homolog 1

Names: SSH-like protein 1; slingshot 1L; slingshot-like 1

NP_001350398.1

EC 3.1.3.16

EC 3.1.3.48

NP_932777.2

EC 3.1.3.16

EC 3.1.3.48

XP_006530351.1

EC 3.1.3.16

EC 3.1.3.48

XP_011246495.1

EC 3.1.3.16

EC 3.1.3.48

XP_030110283.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363469.1 → NP_001350398.1 protein phosphatase Slingshot homolog 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC145559, AK087447, AK173144, BB078364, BY282063

Consensus CDS

CCDS89972.1

Related

ENSMUSP00000107917.4, ENSMUST00000112298.10

Conserved Domains (5) summary

cd11652
Location:3 → 215

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:286 → 422

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:229 → 281

DEK_C; DEK C terminal domain

pfam15782
Location:540 → 744

GREB1; Gene regulated by oestrogen in breast cancer

cl25751
Location:636 → 1015

DUF4045; Domain of unknown function (DUF4045)
NM_198109.5 → NP_932777.2 protein phosphatase Slingshot homolog 1 isoform 1

See identical proteins and their annotated locations for NP_932777.2

Status: VALIDATED

Source sequence(s)

AC145559

Consensus CDS

CCDS19556.1

UniProtKB/Swiss-Prot

Q3TDG3, Q69ZM4, Q76I79, Q811E5

Related

ENSMUSP00000124312.2, ENSMUST00000159592.8

Conserved Domains (3) summary

cd11652
Location:3 → 237

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:308 → 444

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:252 → 303

DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

114075155..114131864 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254423.1 → XP_030110283.1 protein phosphatase Slingshot homolog 1 isoform X2

UniProtKB/TrEMBL

F8WHT2

Related

ENSMUSP00000076873.8, ENSMUST00000077689.14

Conserved Domains (4) summary

PTZ00449
Location:615 → 994

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11652
Location:1 → 194

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14570
Location:263 → 406

DSP_slingshot_1; dual specificity phosphatase domain of slingshot homolog 1

pfam08766
Location:208 → 260

DEK_C; DEK C terminal domain
XM_011248193.4 → XP_011246495.1 protein phosphatase Slingshot homolog 1 isoform X1

Conserved Domains (4) summary

PTZ00449
Location:689 → 1068

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11652
Location:65 → 268

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14570
Location:337 → 480

DSP_slingshot_1; dual specificity phosphatase domain of slingshot homolog 1

pfam08766
Location:282 → 334

DEK_C; DEK C terminal domain
XM_006530288.5 → XP_006530351.1 protein phosphatase Slingshot homolog 1 isoform X2

UniProtKB/TrEMBL

F8WHT2

Conserved Domains (4) summary

PTZ00449
Location:615 → 994

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11652
Location:1 → 194

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14570
Location:263 → 406

DSP_slingshot_1; dual specificity phosphatase domain of slingshot homolog 1

pfam08766
Location:208 → 260

DEK_C; DEK C terminal domain