Tafa3 TAFA chemokine like family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tafa3provided by MGI
Official Full Name: TAFA chemokine like family member 3provided by MGI
Primary source: MGI:MGI:3046463
See related: Ensembl:ENSMUSG00000055865 AllianceGenome:MGI:3046463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sam3; Tafa-3; Fam19a3; 7530404M11Rik
Summary: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis adult (RPKM 2.5), heart adult (RPKM 0.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.84 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (104674721..104686854, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (104767405..104779542, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that TAFA-3 is a signaling molecule from the hypophysial pars tuberalis.
Title: Tafa-3 encoding for a secretory peptide is expressed in the mouse pars tuberalis and is affected by melatonin 1 receptor deficiency.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of microglial cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microglial cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: chemokine-like protein TAFA-3

Names: family with sequence similarity 19, member A3; protein FAM19A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183224.3 → NP_899047.1 chemokine-like protein TAFA-3 precursor

See identical proteins and their annotated locations for NP_899047.1

Status: REVIEWED

Source sequence(s)

AC171110, AK078681

Consensus CDS

CCDS51032.1

UniProtKB/Swiss-Prot

Q147Z7, Q7TPG6

Related

ENSMUSP00000123514.2, ENSMUST00000139783.2

Conserved Domains (1) summary

pfam12020
Location:42 → 130

TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

104674721..104686854 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163140.1 → XP_036019033.1 chemokine-like protein TAFA-3 isoform X1

UniProtKB/Swiss-Prot

Q147Z7, Q7TPG6

Conserved Domains (1) summary

pfam12020
Location:42 → 130

TAFA; TAFA family
XM_017319626.3 → XP_017175115.1 chemokine-like protein TAFA-3 isoform X1

UniProtKB/Swiss-Prot

Q147Z7, Q7TPG6

Conserved Domains (1) summary

pfam12020
Location:42 → 130

TAFA; TAFA family
XM_036163139.1 → XP_036019032.1 chemokine-like protein TAFA-3 isoform X2

Conserved Domains (1) summary

pfam12020
Location:78 → 166

TAFA; TAFA family