Wasf2 WASP family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wasf2provided by MGI
Official Full Name: WASP family, member 2provided by MGI
Primary source: MGI:MGI:1098641
See related: Ensembl:ENSMUSG00000028868 AllianceGenome:MGI:1098641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WAVE2; D4Ertd13e
Summary: Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Involved in postsynaptic actin cytoskeleton organization. Acts upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Located in several cellular components, including early endosome; lamellipodium; and ruffle. Part of SCAR complex. Is active in synapse. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; heart; and yolk sac. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 47.2), lung adult (RPKM 40.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.22 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132857843..132927067)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133130531..133199748)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WAVE2 Is a Vital Regulator in Myogenic Differentiation of Progenitor Cells through the Mechanosensitive MRTFA-SRF Axis.
Title: WAVE2 Is a Vital Regulator in Myogenic Differentiation of Progenitor Cells through the Mechanosensitive MRTFA-SRF Axis.
Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma.
Title: Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma.
Wave complex proteins ABI1 and Wave2 have key roles in regulating signals that control epidermal shape and growth by suppressing Wnt-Sox9 signaling.
Title: The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
WAVE2/c-Abl survival signal required at the hematopoietic stem cell (HSC) fetal liver to marrow transition that confers fitness to the HSC for marrow hematopoiesis
Title: The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. This signaling mechanism may be important for TrkC-mediated cytoskeletal dynamics in podocyte disease.
Title: Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation.
Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology.
Title: The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
Title: Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics.
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex.
Title: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.
This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
Title: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
Results of the present study show that the nucleation-promoting factors JMY and WAVE2 are critical for cytokinesis during development of mouse embryos.
Title: Role of nucleation-promoting factors in mouse early embryo development.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit222 (e-PCR), detects polymorphism
- UniSTS:128563

D1Mit222.1 (e-PCR), detects polymorphism
- UniSTS:128564

AW742646 (e-PCR)
- UniSTS:207689

AW742868 (e-PCR)
- UniSTS:207690

RH125961 (e-PCR)
- UniSTS:162673

RH68756 (e-PCR)
- UniSTS:13967

Wasf2 (e-PCR), detects polymorphism
- UniSTS:256993

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin filament-based movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ameboidal-type cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin-binding protein WASF2

Names: WAS protein family, member 2; WASP family protein member 2; protein WAVE-2; wiskott-Aldrich syndrome protein family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419443.1 → NP_001406372.1 actin-binding protein WASF2

Status: VALIDATED

Source sequence(s)

AL671858

UniProtKB/Swiss-Prot

Q8BH43
NM_001419444.1 → NP_001406373.1 actin-binding protein WASF2

Status: VALIDATED

Source sequence(s)

AL671858

UniProtKB/Swiss-Prot

Q8BH43
NM_153423.7 → NP_700472.1 actin-binding protein WASF2

See identical proteins and their annotated locations for NP_700472.1

Status: VALIDATED

Source sequence(s)

AL671858

Consensus CDS

CCDS18742.1

UniProtKB/Swiss-Prot

Q8BH43

UniProtKB/TrEMBL

Q3T9Z7

Related

ENSMUSP00000081263.6, ENSMUST00000084241.12

Conserved Domains (1) summary

smart00246
Location:435 → 452

WH2; Wiskott Aldrich syndrome homology region 2