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    Zfp207 zinc finger protein 207 [ Mus musculus (house mouse) ]

    Gene ID: 22680, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp207provided by MGI
    Official Full Name
    zinc finger protein 207provided by MGI
    Primary source
    MGI:MGI:1340045
    See related
    Ensembl:ENSMUSG00000017421 AllianceGenome:MGI:1340045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zep; BuGZ; Znf207; 8430401D15Rik
    Summary
    Enables heparin binding activity and microtubule binding activity. Involved in mitotic spindle assembly. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and retina. Orthologous to human ZNF207 (zinc finger protein 207). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 25.2), limb E14.5 (RPKM 24.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 47.83 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80274105..80299387)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80383279..80408561)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:80116169-80116470 Neighboring gene rhomboid like 3 Neighboring gene RIKEN cDNA 5730455P16 gene Neighboring gene STARR-positive B cell enhancer ABC_E7026 Neighboring gene STARR-seq mESC enhancer starr_30146 Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. Malla S, et al. EMBO Rep, 2022 Feb 3. PMID 35037361, Free PMC Article
    2. Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Dai XX, et al. Oncotarget, 2016 May 24. PMID 27177335, Free PMC Article
    3. Zep: A novel zinc finger protein containing a large proline-rich domain. Taguchi E, et al. J Biochem, 1998 Dec 1. PMID 9832628
    4. Phase transition of spindle-associated protein regulate spindle apparatus assembly. Jiang H, et al. Cell, 2015 Sep 24. PMID 26388440, Free PMC Article
    5. BCAS2 is involved in alternative splicing and mouse oocyte development. Zhang J, et al. FASEB J, 2022 Feb. PMID 34972250

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BUB3-interacting and GLEBS motif-containing protein ZNF207
    Names
    49 kDa zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130169.1 → NP_001123641.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1

      See identical proteins and their annotated locations for NP_001123641.1

      Status: VALIDATED

      Source sequence(s)
      AK146787, BB666896, DV661373
      Consensus CDS
      CCDS48863.1
      UniProtKB/Swiss-Prot
      E9PW12, Q99LA2, Q9JMD0, Q9Z326
      Related
      ENSMUSP00000054168.9, ENSMUST00000053740.15
      Conserved Domains (2) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:437 → 472
      SMN; Survival motor neuron protein (SMN)

    2. NM_001130170.1 → NP_001123642.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB013357, AK140139, BB666896, DV661373
      Consensus CDS
      CCDS48865.1
      UniProtKB/Swiss-Prot
      Q9JMD0
      Related
      ENSMUSP00000132968.2, ENSMUST00000165565.8
      Conserved Domains (2) summary
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:382 → 456
      SMN; Survival motor neuron protein (SMN)

    3. NM_001130171.1 → NP_001123643.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 3

      See identical proteins and their annotated locations for NP_001123643.1

      Status: VALIDATED

      Source sequence(s)
      AK146787, AK159683, BB666896, DV661373
      Consensus CDS
      CCDS48864.1
      UniProtKB/Swiss-Prot
      Q9JMD0
      Related
      ENSMUSP00000017567.7, ENSMUST00000017567.14
      Conserved Domains (3) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:406 → 441
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    4. NM_001362721.1 → NP_001349650.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591146, DV661373
      Conserved Domains (2) summary
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:390 → 425
      SMN; Survival motor neuron protein (SMN)

    5. NM_011751.3 → NP_035881.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 4

      See identical proteins and their annotated locations for NP_035881.1

      Status: VALIDATED

      Source sequence(s)
      AB013357, BB666896, DV661373
      UniProtKB/Swiss-Prot
      Q9JMD0
      Conserved Domains (2) summary
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:363 → 437
      SMN; Survival motor neuron protein (SMN)

    RNA

    1. NR_045038.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK087885, BF464890

    2. NR_156116.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    3. NR_156117.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    4. NR_156118.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    5. NR_156119.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    6. NR_156120.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    7. NR_156121.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    8. NR_156122.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591146, BF464890

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80274105..80299387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533189.4 → XP_006533252.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X1

      See identical proteins and their annotated locations for XP_006533252.1

      UniProtKB/Swiss-Prot
      E9PW12, Q99LA2, Q9JMD0, Q9Z326
      Conserved Domains (2) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:437 → 472
      SMN; Survival motor neuron protein (SMN)

    2. XM_036156641.1 → XP_036012534.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2

      Related
      ENSMUSP00000136727.2, ENSMUST00000178665.8
      Conserved Domains (3) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:406 → 441
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RNA

    1. XR_001779976.2 RNA Sequence

    2. XR_001779977.3 RNA Sequence

    3. XR_004936936.1 RNA Sequence

    4. XR_001779978.3 RNA Sequence

    5. XR_004936938.1 RNA Sequence

    6. XR_001779985.3 RNA Sequence

    7. XR_388441.5 RNA Sequence

    8. XR_001779983.3 RNA Sequence

    9. XR_003949420.2 RNA Sequence

    10. XR_003949424.2 RNA Sequence

    11. XR_003949422.2 RNA Sequence

    12. XR_001779990.3 RNA Sequence

    13. XR_003949421.2 RNA Sequence

    14. XR_001779989.3 RNA Sequence

    15. XR_004936937.1 RNA Sequence

    16. XR_004936939.1 RNA Sequence

    17. XR_003949418.2 RNA Sequence

    18. XR_003949419.2 RNA Sequence

    19. XR_388432.3 RNA Sequence

    20. XR_004936935.1 RNA Sequence

    21. XR_003949425.2 RNA Sequence

    22. XR_001779986.3 RNA Sequence

    23. XR_001779988.3 RNA Sequence

    24. XR_001779982.3 RNA Sequence

    25. XR_003949417.2 RNA Sequence

    26. XR_001779991.3 RNA Sequence

    27. XR_004936944.1 RNA Sequence

    28. XR_003949430.1 RNA Sequence

    29. XR_001779996.2 RNA Sequence

    30. XR_003949428.1 RNA Sequence

    31. XR_004936941.1 RNA Sequence

    32. XR_004936942.1 RNA Sequence

    33. XR_004936943.1 RNA Sequence

    34. XR_004936940.1 RNA Sequence

    35. XR_003949416.1 RNA Sequence

    36. XR_003949427.1 RNA Sequence

    37. XR_003949426.1 RNA Sequence

    38. XR_004936945.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMD0.1 GenPept UniProtKB/Swiss-Prot:Q9JMD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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