Tmem59 transmembrane protein 59 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem59provided by MGI
Official Full Name: transmembrane protein 59provided by MGI
Primary source: MGI:MGI:1929278
See related: Ensembl:ENSMUSG00000028618 AllianceGenome:MGI:1929278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ORF18; MTDCF1; D4Ertd20e; 1110001M20Rik; 3110046P06Rik
Summary: Enables endopeptidase activity. Predicted to be involved in negative regulation of cellular protein metabolic process; negative regulation of protein localization to plasma membrane; and positive regulation of autophagy. Predicted to act upstream of or within autophagy. Predicted to be located in Golgi cis cisterna; Golgi medial cisterna; and Golgi trans cisterna. Predicted to be active in late endosome and lysosome. Is expressed in several structures, including alveolar sulcus; central nervous system; olfactory epithelium; retina; and skeleton. Orthologous to human TMEM59 (transmembrane protein 59). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 174.0), colon adult (RPKM 122.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.12 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (107035827..107058193)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (107178630..107200996)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency.
Title: The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency.
Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.
Title: Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.
A preliminary study on abnormal brain function and autistic behavior in mice caused by dcf1 deletion.
Title: A preliminary study on abnormal brain function and autistic behavior in mice caused by dcf1 deletion.
Dendritic cell factor 1 deletion leads to developmental defects in mushroom-shaped dendritic spines.
Title: Dendritic cell factor 1 deletion leads to developmental defects in mushroom-shaped dendritic spines.
Deletion of Dcf1 Reduces Amyloid-beta Aggregation and Mitigates Memory Deficits.
Title: Deletion of Dcf1 Reduces Amyloid-β Aggregation and Mitigates Memory Deficits.
TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation.
Title: TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation.
TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Title: TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Dcf1 deletion presents alterations in gut microbiota of mice similar to Parkinson's disease.
Title: Dcf1 deletion presents alterations in gut microbiota of mice similar to Parkinson's disease.
Dcf1 protein affects both memory and anxiety by regulating NMDA and AMPA receptors.
Title: Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors.
Dcf1 triggers the dendritic spine and synaptic function through the recruitment of Lcn2 and activation of PSD95-NMDAR signaling.
Title: Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

AI256529 (e-PCR)
- UniSTS:179044

RH125981 (e-PCR)
- UniSTS:162693

RH138551 (e-PCR)
- UniSTS:220638

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect protein glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 59

Names: thymic dendritic cell-derived factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.