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    Adh1 alcohol dehydrogenase 1 (class I) [ Mus musculus (house mouse) ]

    Gene ID: 11522, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Adh1provided by MGI
    Official Full Name
    alcohol dehydrogenase 1 (class I)provided by MGI
    Primary source
    MGI:MGI:87921
    See related
    Ensembl:ENSMUSG00000074207 AllianceGenome:MGI:87921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh-1; ADH-A2; ADH-AA; Adh-1e; Adh-1t; Adh-3e; Adh1-e; Adh1-t; Adh1tl; Adh3-e; Adh-1-t
    Summary
    Enables alcohol dehydrogenase (NAD+) activity and identical protein binding activity. Acts upstream of or within several processes, including behavioral response to ethanol; ethanol catabolic process; and retinoid metabolic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; epidermis; genitourinary system; intestine; and sensory organ. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 1139.9), adrenal adult (RPKM 886.1) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G3; 3 64.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137983346..137996459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138277585..138290698)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Neighboring gene predicted gene, 40156 Neighboring gene Adh1 promoter region Neighboring gene predicted gene 16559 Neighboring gene alcohol dehydrogenase 6A (class V)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway. Li S, et al. Acta Pharmacol Sin, 2022 Oct. PMID 35354963, Free PMC Article
    2. Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1. Petrosino JM, et al. J Clin Invest, 2021 Feb 15. PMID 33586683, Free PMC Article
    3. ALDH expression characterizes G1-phase proliferating beta cells during pregnancy. Zhang L, et al. PLoS One, 2014. PMID 24787690, Free PMC Article
    4. Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms. Vasdev S, et al. Vasc Health Risk Manag, 2006. PMID 17326332, Free PMC Article
    5. Individual susceptibility and alcohol effects:biochemical and genetic aspects. Gemma S, et al. Ann Ist Super Sanita, 2006. PMID 16801720

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
      Title: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
    2. Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.
      Title: Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.
    3. It is responsible for systemic alcohol metabolism.
      Title: Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.
    4. Overexpression of an ADH1 transgene protected against tunicamycin-induced cardiac dysfunction through attenuation of ER stress, oxidative stress, and PTEN-Akt-mTOR regulated autophagy.
      Title: Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
    5. Data indicate a potential change in aldehyde dehydrogenase (ALDH) activity of proliferating beta cells during pregnancy.
      Title: ALDH expression characterizes G1-phase proliferating beta cells during pregnancy.
    6. regulation of human class I alcohol dehydrogenases by bile acids
      Title: Regulation of human class I alcohol dehydrogenases by bile acids.
    7. This study demonistrated that adh1 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
      Title: Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
    8. Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase
      Title: Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.
    9. Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization.
      Title: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.
    10. Cellular expression of Adh1 in the GI tract was studied.
      Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity, zinc-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ethanol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetaldehyde biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ethanol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to steroid hormone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to testosterone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinoic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinoic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alcohol dehydrogenase 1
    Names
    alcohol dehydrogenase 1 temporal, liver
    alcohol dehydrogenase 1, complex
    alcohol dehydrogenase 1, electrophoretic
    alcohol dehydrogenase 3, electrophoretic
    alcohol dehydrogenase A subunit
    class I alcohol dehydrogenase
    NP_031435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007409.3 → NP_031435.1  alcohol dehydrogenase 1

      See identical proteins and their annotated locations for NP_031435.1

      Status: VALIDATED

      Source sequence(s)
      AC079682, AI256543, AI326887, CD355981, DV044803
      Consensus CDS
      CCDS17867.1
      UniProtKB/Swiss-Prot
      P00329
      UniProtKB/TrEMBL
      Q3UKA4
      Related
      ENSMUSP00000004232.10, ENSMUST00000004232.10
      Conserved Domains (2) summary
      cd08299
      Location:3 → 375
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:8 → 375
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137983346..137996459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00329.2 GenPept UniProtKB/Swiss-Prot:P00329

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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