Toe1 target of EGR1, member 1 (nuclear) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Toe1provided by MGI
Official Full Name: target of EGR1, member 1 (nuclear)provided by MGI
Primary source: MGI:MGI:1915526
See related: Ensembl:ENSMUSG00000028688 AllianceGenome:MGI:1915526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930584N22Rik; 4933424D16Rik
Summary: Predicted to enable poly(A)-specific ribonuclease activity and snRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Predicted to be located in nuclear body. Predicted to be active in Cajal body and cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 18.1), testis adult (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.33 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116661199..116664785, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116804003..116807601, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice.
Title: Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables snRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in snRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA 3'-end processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: target of EGR1 protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.