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    Zbtb43 zinc finger and BTB domain containing 43 [ Mus musculus (house mouse) ]

    Gene ID: 71834, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zbtb43provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 43provided by MGI
    Primary source
    MGI:MGI:1919084
    See related
    Ensembl:ENSMUSG00000026788 AllianceGenome:MGI:1919084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp297b; mKIAA0414; 1700010E06Rik
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ZBTB43 (zinc finger and BTB domain containing 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 5.6), CNS E18 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 22.46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33340299..33358592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33450287..33468581, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene STARR-seq mESC enhancer starr_04240 Neighboring gene STARR-seq mESC enhancer starr_04241 Neighboring gene predicted gene 13536 Neighboring gene STARR-seq mESC enhancer starr_04242 Neighboring gene predicted gene 13530 Neighboring gene predicted gene, 33642

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome. Meng Y, et al. Nat Cell Biol, 2022 Jul. PMID 35787683, Free PMC Article
    2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    3. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 43
    Names
    ortholog of zinc finger protein 297B ZNF297B
    zinc finger protein 297B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025594.1 → NP_001020765.1  zinc finger and BTB domain-containing protein 43 isoform b

      See identical proteins and their annotated locations for NP_001020765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL929212, BC043117
      Consensus CDS
      CCDS15943.1
      UniProtKB/Swiss-Prot
      Q9DAI4
      UniProtKB/TrEMBL
      Q3UGQ6
      Related
      ENSMUSP00000028125.6, ENSMUST00000028125.12
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001355610.1 → NP_001342539.1  zinc finger and BTB domain-containing protein 43 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AL929212, DV650463
      Consensus CDS
      CCDS15942.1
      UniProtKB/TrEMBL
      G3X9N4, Q3UGQ6
      Conserved Domains (3) summary
      sd00017
      Location:413 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:60 → 160
      BTB; BTB/POZ domain
      pfam13465
      Location:451 → 474
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001355611.1 → NP_001342540.1  zinc finger and BTB domain-containing protein 43 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL929212
      Consensus CDS
      CCDS15943.1
      UniProtKB/Swiss-Prot
      Q9DAI4
      UniProtKB/TrEMBL
      Q3UGQ6
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001355612.1 → NP_001342541.1  zinc finger and BTB domain-containing protein 43 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL929212, CV676247
      Consensus CDS
      CCDS15943.1
      UniProtKB/Swiss-Prot
      Q9DAI4
      UniProtKB/TrEMBL
      Q3UGQ6
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain

    5. NM_027947.2 → NP_082223.2  zinc finger and BTB domain-containing protein 43 isoform a

      See identical proteins and their annotated locations for NP_082223.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AK005818, AL929212, BC043117
      Consensus CDS
      CCDS15942.1
      UniProtKB/TrEMBL
      G3X9N4, Q3UGQ6
      Related
      ENSMUSP00000108781.3, ENSMUST00000113156.2
      Conserved Domains (3) summary
      sd00017
      Location:413 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:60 → 160
      BTB; BTB/POZ domain
      pfam13465
      Location:451 → 474
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      33340299..33358592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498349.4 → XP_006498412.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_006498412.1

      UniProtKB/Swiss-Prot
      Q9DAI4
      UniProtKB/TrEMBL
      Q3UGQ6
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAI4.2 GenPept UniProtKB/Swiss-Prot:Q9DAI4

    Gene LinkOut

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