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    Klf15 Kruppel-like factor 15 [ Mus musculus (house mouse) ]

    Gene ID: 66277, updated on 19-Sep-2021

    Summary

    Official Symbol
    Klf15provided by MGI
    Official Full Name
    Kruppel-like factor 15provided by MGI
    Primary source
    MGI:MGI:1929988
    See related
    Ensembl:ENSMUSG00000030087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CKL; KKL; CKLF; KKLF; hlb44; hlb444; AV048136; AW494632; 1810013I09Rik
    Expression
    Broad expression in liver adult (RPKM 36.3), kidney adult (RPKM 26.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Klf15 in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90437785..90468785)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90461043..90491803)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (90412620..90425203)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene predicted gene 15756 Neighboring gene solute carrier family 41, member 3 Neighboring gene predicted gene, 53296

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cardiac muscle hypertrophy in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular visceral epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 15
    Names
    cardiovascular Krueppel-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355668.1NP_001342597.1  Krueppel-like factor 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163346
      Conserved Domains (2) summary
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:320344
      zf-C2H2; Zinc finger, C2H2 type
    2. NM_023184.4NP_075673.1  Krueppel-like factor 15 isoform 1

      See identical proteins and their annotated locations for NP_075673.1

      Status: VALIDATED

      Source sequence(s)
      AC163346
      Consensus CDS
      CCDS20360.1
      UniProtKB/Swiss-Prot
      Q9EPW2
      Related
      ENSMUSP00000032174.6, ENSMUST00000032174.12
      Conserved Domains (4) summary
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:320344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:366391
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:322401
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      90437785..90468785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255539.2XP_030111399.1  Krueppel-like factor 15 isoform X4

      Conserved Domains (3) summary
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:320344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:336358
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006506472.4XP_006506535.1  Krueppel-like factor 15 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:427449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:425449
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:441463
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011241425.3XP_011239727.1  Krueppel-like factor 15 isoform X3

      Conserved Domains (3) summary
      sd00017
      Location:427449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:425449
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:441463
      zf-H2C2_2; Zinc-finger double domain
    4. XM_006506471.4XP_006506534.1  Krueppel-like factor 15 isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:423505
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:427449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:471496
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_003956249.2 RNA Sequence

    2. XR_003956248.2 RNA Sequence

    3. XR_377485.4 RNA Sequence

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