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    Ano9 anoctamin 9 [ Mus musculus (house mouse) ]

    Gene ID: 71345, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ano9provided by MGI
    Official Full Name
    anoctamin 9provided by MGI
    Primary source
    MGI:MGI:1918595
    See related
    Ensembl:ENSMUSG00000054662 AllianceGenome:MGI:1918595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp53i5; Tmem16j; Trp53i5; 5430425C04Rik
    Summary
    Enables phospholipid scramblase activity. Acts upstream of or within calcium activated galactosylceramide scrambling; calcium activated phosphatidylcholine scrambling; and calcium activated phosphatidylserine scrambling. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in gut epithelium; lung epithelium; rib cartilage condensation; and skin. Orthologous to human ANO9 (anoctamin 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 44.3), duodenum adult (RPKM 20.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 86.37 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140681125..140697719, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141101212..141117806, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene plakophilin 3 Neighboring gene STARR-positive B cell enhancer ABC_E2255 Neighboring gene single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene phosphatidylserine synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction. Kim H, et al. Prog Neurobiol, 2022 Dec. PMID 36330924
    2. Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal. Kim H, et al. Cell Calcium, 2018 May. PMID 29604966
    3. Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico. Katoh M, et al. Int J Oncol, 2004 Jul. PMID 15202010
    4. Expression of TMEM16 paralogs during murine embryogenesis. Rock JR, et al. Dev Dyn, 2008 Sep. PMID 18729231
    5. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
      Title: Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
    2. ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function.
      Title: Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium activated galactosylceramide scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium activated phosphatidylserine scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plasma membrane phospholipid scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-9
    Names
    Trp53 inducible protein 5
    transformation related protein 53 inducible protein 5
    transmembrane protein 16J
    tumor protein p53 inducible protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178381.3 → NP_848468.2  anoctamin-9

      See identical proteins and their annotated locations for NP_848468.2

      Status: PROVISIONAL

      Source sequence(s)
      AC109272, BB158112, BY717147, CF896275
      Consensus CDS
      CCDS52438.1
      UniProtKB/Swiss-Prot
      P86044
      Related
      ENSMUSP00000067689.8, ENSMUST00000067836.9
      Conserved Domains (2) summary
      pfam04547
      Location:174 → 730
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:105 → 171
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140681125..140697719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536248.4 → XP_006536311.2  anoctamin-9 isoform X1

      Conserved Domains (2) summary
      pfam04547
      Location:192 → 747
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:123 → 189
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_006536250.2 → XP_006536313.1  anoctamin-9 isoform X3

      Conserved Domains (1) summary
      pfam04547
      Location:30 → 585
      Anoctamin; Calcium-activated chloride channel

    3. XM_011249856.4 → XP_011248158.1  anoctamin-9 isoform X4

      Related
      ENSMUST00000211515.2
      Conserved Domains (1) summary
      pfam04547
      Location:23 → 499
      Anoctamin; Calcium-activated chloride channel

    4. XM_006536249.3 → XP_006536312.2  anoctamin-9 isoform X2

      Conserved Domains (2) summary
      pfam04547
      Location:192 → 632
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:123 → 189
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86044.1 GenPept UniProtKB/Swiss-Prot:P86044

    Gene LinkOut

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