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    Myo1d myosin ID [ Mus musculus (house mouse) ]

    Gene ID: 338367, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Myo1dprovided by MGI
    Official Full Name
    myosin IDprovided by MGI
    Primary source
    MGI:MGI:107728
    See related
    Ensembl:ENSMUSG00000035441 AllianceGenome:MGI:107728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D11Ertd9e; myosin-1d; 9930104H07Rik
    Summary
    Predicted to enable several functions, including actin filament binding activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in cellular localization. Located in several cellular components, including brush border; myelin sheath; and neuronal cell body. Is expressed in alimentary system; foot; and sensory organ. Orthologous to human MYO1D (myosin ID). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 42.4), colon adult (RPKM 39.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myo1d in Genome Data Viewer
    Location:
    11 B5; 11 47.95 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80372945..80670881, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80482126..80780055, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Neighboring gene RIKEN cDNA C030013C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1835 Neighboring gene STARR-positive B cell enhancer ABC_E9833 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1 Neighboring gene predicted gene, 53690 Neighboring gene STARR-seq mESC enhancer starr_30150 Neighboring gene predicted gene, 31109 Neighboring gene predicted gene, 38907 Neighboring gene STARR-seq mESC enhancer starr_30152 Neighboring gene STARR-positive B cell enhancer mm9_chr11:80524920-80525220 Neighboring gene predicted gene, 31042 Neighboring gene predicted gene, 31228 Neighboring gene 39S ribosomal protein L27, mitochondrial pseudogene Neighboring gene transmembrane protein 98

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The class I myosin MYO1D binds to lipid and protects against colitis. McAlpine W, et al. Dis Model Mech, 2018 Sep 27. PMID 30279225, Free PMC Article
    2. Myosin Id localizes in dendritic spines through the tail homology 1 domain. Koshida R, et al. Exp Cell Res, 2018 Jun 1. PMID 29559226
    3. New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D. Ko YS, et al. Clin Transl Med, 2021 Aug. PMID 34459138, Free PMC Article
    4. Expression and localization of myosin-1d in the developing nervous system. Benesh AE, et al. Brain Res, 2012 Feb 27. PMID 22284616, Free PMC Article
    5. Proteomic analysis of the enterocyte brush border. McConnell RE, et al. Am J Physiol Gastrointest Liver Physiol, 2011 May. PMID 21330445, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D.
      Title: New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D.
    2. these findings reveal that myosin Id localizes in dendritic spines through the TH1 domain.
      Title: Myosin Id localizes in dendritic spines through the tail homology 1 domain.
    3. MYO1D is needed to maintain epithelial integrity and protect against dextran sodium sulfate-induced colitis.
      Title: The class I myosin MYO1D binds to lipid and protects against colitis.
    4. analysis of myosin-1d expression patterns in the peripheral and central nervous systems during postnatal development
      Title: Expression and localization of myosin-1d in the developing nervous system.
    5. Data suggest that Myo1d may be the primary compensating class I myosin in the Myo1a KO model; they also suggest that dynamics govern the localization and function of different yet closely related myosins that target common actin structures.
      Title: Differential localization and dynamics of class I myosins in the enterocyte microvillus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183676

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-Id
    Names
    myosin-Id

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177390.3 → NP_796364.2  unconventional myosin-Id

      See identical proteins and their annotated locations for NP_796364.2

      Status: VALIDATED

      Source sequence(s)
      AK049374, AK148112
      Consensus CDS
      CCDS36242.1
      UniProtKB/Swiss-Prot
      Q5SSK7, Q5SYD0, Q8BWY5
      UniProtKB/TrEMBL
      B2RWZ2
      Related
      ENSMUSP00000037819.8, ENSMUST00000041065.14
      Conserved Domains (3) summary
      smart00242
      Location:4 → 694
      MYSc; Myosin. Large ATPases
      cd01378
      Location:24 → 682
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:803 → 997
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80372945..80670881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156783.1 → XP_036012676.1  unconventional myosin-Id isoform X1

      UniProtKB/TrEMBL
      B2RWZ2
      Conserved Domains (2) summary
      cd01378
      Location:36 → 686
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:807 → 1000
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. XM_011249085.3 → XP_011247387.1  unconventional myosin-Id isoform X5

      UniProtKB/TrEMBL
      Q3UG58
      Conserved Domains (2) summary
      cl22853
      Location:14 → 183
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:304 → 497
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. XM_006533585.2 → XP_006533648.1  unconventional myosin-Id isoform X3

      UniProtKB/TrEMBL
      B2RWZ2
      Related
      ENSMUSP00000066948.6, ENSMUST00000070997.6
      Conserved Domains (2) summary
      cd01378
      Location:24 → 682
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:803 → 906
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    4. XM_036156784.1 → XP_036012677.1  unconventional myosin-Id isoform X2

      UniProtKB/TrEMBL
      B2RWZ2
      Conserved Domains (2) summary
      cd01378
      Location:36 → 686
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:807 → 910
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    5. XM_036156785.1 → XP_036012678.1  unconventional myosin-Id isoform X4

      Conserved Domains (1) summary
      cl22853
      Location:36 → 517
      Motor_domain; Myosin and Kinesin motor domain

    RNA

    1. XR_003949464.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SYD0.1 GenPept UniProtKB/Swiss-Prot:Q5SYD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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