Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4a10provided by MGI
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 10provided by MGI
Primary source: MGI:MGI:88611
See related: Ensembl:ENSMUSG00000066072 AllianceGenome:MGI:88611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RP1; Cyp4a; D4Rp1; Msp-3
Summary: Predicted to enable 16-hydroxypalmitate dehydrogenase activity and monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to act upstream of or within lipid metabolic process. Located in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A11 (cytochrome P450 family 4 subfamily A member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 205.5), kidney adult (RPKM 150.4) and 1 other tissue See more
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Genomic context

Location:: 4 D1; 4 53.05 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115375484..115390846)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115518287..115533649)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results implicate Cyp4a10 and Cyp4a14 in the regulation of the host inflammatory response to enteropathogenic bacterial infection but not to acute aseptic inflammation.
Title: Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.
High salt triggers possible A(2A)AR-induced relaxation through CYP epoxygenase in both eNOS(+/+) and eNOS(-/-).
Title: Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.
Role of CYP4A in reactive oxygen species production ad apoptosis of podocytes in a mouse model of type 1 diabetes.
Title: Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
"Cytochromes P450 4A metabolize arachidonic acid into hydroxyeicosatetraenoic acids (HETEs) that exhibit potent actions on airway smooth muscle tone." p. 181
Title: Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.
Results show that disruption of the murine cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10) gene causes a type of hypertension that is, like most human hypertension, dietary salt sensitive.
Title: Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Cyp4a10 (e-PCR), detects polymorphism
- UniSTS:463006

Cyp4a10 (e-PCR), detects polymorphism
- UniSTS:546725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonic acid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4A10

Names: CYPIVA10; cytochrome P450, 4a10; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase

NP_034141.3

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.