Bptf bromodomain PHD finger transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bptfprovided by MGI
Official Full Name: bromodomain PHD finger transcription factorprovided by MGI
Primary source: MGI:MGI:2444008
See related: Ensembl:ENSMUSG00000040481 AllianceGenome:MGI:2444008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Falz; 9430093H17Rik
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Acts upstream of or within anterior/posterior pattern specification; embryonic placenta development; and endoderm development. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of NURF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human BPTF (bromodomain PHD finger transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 10.4), CNS E11.5 (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 E1; 11 70.11 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106923907..107022982, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (107033081..107132147, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Title: Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Bptf determines oncogenic addiction in aggressive B-cell lymphomas.
Title: Bptf determines oncogenic addiction in aggressive B-cell lymphomas.
An essential requirement of the chromatin remodeler BPTF and NURF for activation of "stemness" gene-expression programs and proper function of adult HSCs.
Title: The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.
This study implicates BPTF in maintaining the unique epigenetic state of mammary gland stem cells.
Title: BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.
enhanced activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.
Title: BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity.
These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
Title: BPTF Is Essential for T Cell Homeostasis and Function.
We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.
Title: Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
Title: Functional interactions between NURF and Ctcf regulate gene expression.
study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo
Title: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Results suggest that BPTF/FAC1 is essential in the extraembryonic lineage for correct development of the ectoplacental cone and fetomaternal interactions.
Title: Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATPase complex	ISO Inferred from Sequence Orthology more info
part_of NURF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NURF complex	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: nucleosome-remodeling factor subunit BPTF

Names: fetal Alzheimer antigen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359590.2 → NP_001346519.1 nucleosome-remodeling factor subunit BPTF isoform 3

Status: VALIDATED

Source sequence(s)

AL596116

UniProtKB/TrEMBL

E5D6T0

Conserved Domains (8) summary

cd05509
Location:2673 → 2773

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2611 → 2657

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:1965 → 2386

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

cl25742
Location:2406 → 2528

ERM; Ezrin/radixin/moesin family
NM_176850.3 → NP_789820.2 nucleosome-remodeling factor subunit BPTF isoform 2

Status: VALIDATED

Source sequence(s)

AL596116

Consensus CDS

CCDS48964.1

UniProtKB/TrEMBL

A2A655, E9Q6A7

Related

ENSMUSP00000052303.9, ENSMUST00000057892.15

Conserved Domains (6) summary

cd05509
Location:2806 → 2906

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2744 → 2790

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03955
Location:2080 → 2169

Adeno_PIX; Adenovirus hexon-associated protein (IX)

pfam15612
Location:351 → 400

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

106923907..107022982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532690.3 → XP_006532753.1 nucleosome-remodeling factor subunit BPTF isoform X23

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2798 → 2898

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2736 → 2782

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2531 → 2653

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_036156484.1 → XP_036012377.1 nucleosome-remodeling factor subunit BPTF isoform X20

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2856 → 2956

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2794 → 2840

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2531 → 2656

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033845
Location:579 → 752

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_006532686.4 → XP_006532749.1 nucleosome-remodeling factor subunit BPTF isoform X12

UniProtKB/TrEMBL

A2A654

Related

ENSMUSP00000102374.2, ENSMUST00000106763.8

Conserved Domains (9) summary

cd05509
Location:2931 → 3031

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2869 → 2915

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2192 → 2555

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2642 → 2782

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_017314399.3 → XP_017169888.1 nucleosome-remodeling factor subunit BPTF isoform X19

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:2852 → 2952

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2790 → 2836

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2194 → 2572

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2585 → 2707

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_030245733.2 → XP_030101593.1 nucleosome-remodeling factor subunit BPTF isoform X16

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:2910 → 3010

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2848 → 2894

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2194 → 2572

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2585 → 2707

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_006532685.2 → XP_006532748.1 nucleosome-remodeling factor subunit BPTF isoform X11

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2923 → 2969

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)

cl02556
Location:2985 → 3030

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006532680.2 → XP_006532743.1 nucleosome-remodeling factor subunit BPTF isoform X6

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:2985 → 3085

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2923 → 2969

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_006532684.4 → XP_006532747.1 nucleosome-remodeling factor subunit BPTF isoform X10

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:2985 → 3085

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2923 → 2969

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_006532678.2 → XP_006532741.1 nucleosome-remodeling factor subunit BPTF isoform X4

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2981 → 3027

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)

cl02556
Location:3043 → 3088

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006532675.2 → XP_006532738.1 nucleosome-remodeling factor subunit BPTF isoform X1

See identical proteins and their annotated locations for XP_006532738.1

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:3043 → 3143

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2981 → 3027

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_006532677.4 → XP_006532740.1 nucleosome-remodeling factor subunit BPTF isoform X3

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:3043 → 3143

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2981 → 3027

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2246 → 2609

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2696 → 2836

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_006532687.3 → XP_006532750.1 nucleosome-remodeling factor subunit BPTF isoform X14

UniProtKB/TrEMBL

A2A655

Conserved Domains (9) summary

cd05509
Location:2918 → 3018

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2856 → 2902

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2121 → 2484

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2571 → 2711

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:1913 → 2220

DUF5585; Family of unknown function (DUF5585)
XM_006532683.3 → XP_006532746.1 nucleosome-remodeling factor subunit BPTF isoform X9

UniProtKB/TrEMBL

A2A655

Conserved Domains (10) summary

cd05509
Location:2979 → 3079

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2917 → 2963

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2182 → 2545

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2632 → 2772

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:1974 → 2281

DUF5585; Family of unknown function (DUF5585)

NF000535
Location:519 → 653

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
XM_006532682.3 → XP_006532745.1 nucleosome-remodeling factor subunit BPTF isoform X8

UniProtKB/TrEMBL

A2A655

Conserved Domains (10) summary

cd05509
Location:2980 → 3080

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2918 → 2964

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2183 → 2546

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2633 → 2773

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:1975 → 2282

DUF5585; Family of unknown function (DUF5585)

NF000535
Location:519 → 687

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
XM_006532681.3 → XP_006532744.1 nucleosome-remodeling factor subunit BPTF isoform X7

UniProtKB/TrEMBL

A2A655

Conserved Domains (9) summary

cd05509
Location:2981 → 3081

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2919 → 2965

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2184 → 2547

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2634 → 2774

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:1976 → 2283

DUF5585; Family of unknown function (DUF5585)
XM_006532676.3 → XP_006532739.1 nucleosome-remodeling factor subunit BPTF isoform X2

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:3042 → 3142

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 748

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2980 → 3026

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2245 → 2608

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2695 → 2835

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2037 → 2344

DUF5585; Family of unknown function (DUF5585)
XM_006532679.3 → XP_006532742.1 nucleosome-remodeling factor subunit BPTF isoform X5

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2989 → 3089

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2927 → 2973

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2192 → 2555

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02791
Location:253 → 309

DDT; DDT domain

pfam13868
Location:2642 → 2782

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_036156488.1 → XP_036012381.1 nucleosome-remodeling factor subunit BPTF isoform X26

UniProtKB/TrEMBL

E5D6T0

Conserved Domains (8) summary

cd05509
Location:2731 → 2831

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2669 → 2715

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2015 → 2393

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2406 → 2531

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_036156486.1 → XP_036012379.1 nucleosome-remodeling factor subunit BPTF isoform X24

UniProtKB/TrEMBL

A2A654

Conserved Domains (8) summary

cd05509
Location:2794 → 2894

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2732 → 2778

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2078 → 2456

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2469 → 2594

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_006532689.3 → XP_006532752.1 nucleosome-remodeling factor subunit BPTF isoform X18

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2856 → 2956

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2794 → 2840

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2531 → 2653

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_006532688.3 → XP_006532751.1 nucleosome-remodeling factor subunit BPTF isoform X15

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

cd05509
Location:2910 → 3010

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2848 → 2894

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2194 → 2572

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2585 → 2707

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)
XM_030245735.2 → XP_030101595.1 nucleosome-remodeling factor subunit BPTF isoform X22

UniProtKB/TrEMBL

A2A654

Conserved Domains (10) summary

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2790 → 2836

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:253 → 309

DDT; DDT domain

pfam03157
Location:2194 → 2572

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2585 → 2707

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam17823
Location:2038 → 2345

DUF5585; Family of unknown function (DUF5585)

cl02556
Location:2852 → 2897

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_036156483.1 → XP_036012376.1 nucleosome-remodeling factor subunit BPTF isoform X17

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2848 → 2894

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2194 → 2572

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2585 → 2710

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033845
Location:579 → 752

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

cl02556
Location:2910 → 2955

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_036156487.1 → XP_036012380.1 nucleosome-remodeling factor subunit BPTF isoform X25

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2798 → 2898

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2736 → 2782

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2531 → 2656

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033845
Location:579 → 752

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_036156485.1 → XP_036012378.1 nucleosome-remodeling factor subunit BPTF isoform X21

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2794 → 2840

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2531 → 2656

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

cl02556
Location:2856 → 2901

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_036156482.1 → XP_036012375.1 nucleosome-remodeling factor subunit BPTF isoform X13

UniProtKB/TrEMBL

A2A654

Conserved Domains (9) summary

cd05509
Location:2931 → 3031

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:252 → 311

DDT; domain in different transcription and chromosome remodeling factors

COG5271
Location:578 → 749

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd15559
Location:404 → 446

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2869 → 2915

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam03157
Location:2140 → 2518

Glutenin_hmw; High molecular weight glutenin subunit

pfam13868
Location:2643 → 2789

TPH; Trichohyalin-plectin-homology domain

pfam15612
Location:356 → 393

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:468 → 536

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001080832.1: Suppressed sequence

Description

NM_001080832.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.