Grik1 glutamate receptor, ionotropic, kainate 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grik1provided by MGI
Official Full Name: glutamate receptor, ionotropic, kainate 1provided by MGI
Primary source: MGI:MGI:95814
See related: Ensembl:ENSMUSG00000022935 AllianceGenome:MGI:95814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluK1; GluK5; Glur5; Glur-5; D16Ium24; D16Ium24e; Glurbeta1; A830007B11Rik
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in CNS E18 (RPKM 5.8), whole brain E14.5 (RPKM 2.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 50.23 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (87692789..88087751, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (87895901..88290863, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms.
Title: Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms.
Revisiting the Radiosynthesis of [(18)F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease.
Title: Revisiting the Radiosynthesis of [(18)F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease.
The suppressing activity of mGlu1 receptors on mGlu5 receptor was maintained in mature PCs, suggesting that expression of mGlu1alpha and mGlu5 receptors is mutually exclusive in Purkinje cells. These findings add complexity to the the finely tuned mechanisms that regulate PC biology during development and in the adult life and lay the groundwork for an in-depth analysis of the role played by mGlu5 receptors in PC matur...
Title: mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors.
These effects correlate with the mGluR5 over-expression.
Title: mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction.
loss of FMRP leads to the abnormal function and localization of kainite receptors.
Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
Data (including data from in vitro studies using tissues from transgenic mice) suggest that vitamin D3 suppresses NMDA-receptor- (Grin1)-mediated and kainate-receptor- (Grik1)-mediated excitation of GnRH- (gonadotrophin-releasing hormone)-secreting neurons of pre-optic area of hypothalamus. These studies were conducted with brain slices from male and female mice in pre-pubertal period.
Title: Non-genomic action of vitamin D3 on N-methyl-D-aspartate and kainate receptor-mediated actions in juvenile gonadotrophin-releasing hormone neurons.
The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
Title: Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.
GluK5 is almost exclusively localized to the presynaptic ribbon of photoreceptor terminals.
Title: Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.
These data reveal some requirements for kainate receptor targeting to the synapse, indicating a fundamental role of high affinity kainate receptor subunits in this process.
Title: Synaptic Targeting of Kainate Receptors.
These results establish critical roles for Neto auxiliary subunits controlling Kainate receptor properties and synaptic incorporation.
Title: Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa52d8.seq (e-PCR)
- UniSTS:125192

Grik1 (e-PCR), detects polymorphism
- UniSTS:259083

Grik1 (e-PCR), detects polymorphism
- UniSTS:259612

U23914 (e-PCR)
- UniSTS:69680

MHAa21c11.seq (e-PCR)
- UniSTS:125081

46.MMHAP64FRH10.seq (e-PCR)
- UniSTS:124629

D16Ium72 (e-PCR), detects polymorphism
- UniSTS:142071

Grik1 (e-PCR), detects polymorphism
- UniSTS:546807

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables extracellularly glutamate-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables kainate selective glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables kainate selective glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amino acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of synaptic transmission, glutamatergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within presynaptic modulation of chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of ionotropic glutamate receptor complex	IC Inferred by Curator more info	PubMed
part_of ionotropic glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kainate selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 1

Names: glutamate receptor subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346964.2 → NP_001333893.2 glutamate receptor ionotropic, kainate 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 3' exon structure, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform c, which has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC093479, AC118681, CT030723

Consensus CDS

CCDS84256.1

UniProtKB/TrEMBL

A0A1B0GSI4, A0A2I3BRJ1

Related

ENSMUSP00000147948.2, ENSMUST00000211444.2

Conserved Domains (2) summary

cd06382
Location:38 → 416

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:431 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001405028.1 → NP_001391957.1 glutamate receptor ionotropic, kainate 1 isoform d

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723

UniProtKB/TrEMBL

A0A2I3BPT2

Related

ENSMUSP00000153786.2, ENSMUST00000227986.2
NM_001405029.1 → NP_001391958.1 glutamate receptor ionotropic, kainate 1 isoform e

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723

UniProtKB/TrEMBL

A0A2I3BQM2

Related

ENSMUSP00000154130.2, ENSMUST00000228188.2
NM_001405030.1 → NP_001391959.1 glutamate receptor ionotropic, kainate 1 isoform f

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723

Related

ENSMUSP00000154596.2, ENSMUST00000228034.2
NM_001405031.1 → NP_001391960.1 glutamate receptor ionotropic, kainate 1 isoform g

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723
NM_001405032.1 → NP_001391961.1 glutamate receptor ionotropic, kainate 1 isoform h

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723
NM_001405033.1 → NP_001391962.1 glutamate receptor ionotropic, kainate 1 isoform i

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723
NM_001405034.1 → NP_001391963.1 glutamate receptor ionotropic, kainate 1 isoform j

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723
NM_001405035.1 → NP_001391964.1 glutamate receptor ionotropic, kainate 1 isoform k precursor

Status: REVIEWED

Source sequence(s)

AC093479, AC118681, CT030723

UniProtKB/TrEMBL

Q8C825
NM_010348.4 → NP_034478.2 glutamate receptor ionotropic, kainate 1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to transcript variant 1, resulting in a shorter isoform (b) lacking a 29 aa segment compared to isoform a.

Source sequence(s)

AC093479, AC118681, CT030723

Consensus CDS

CCDS84254.1

UniProtKB/TrEMBL

F6Z3M4, Q3UZT1

Related

ENSMUSP00000023652.10, ENSMUST00000023652.16

Conserved Domains (2) summary

cd06382
Location:38 → 416

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:431 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_146072.5 → NP_666184.3 glutamate receptor ionotropic, kainate 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AC093479, AC118681, CT030723

Consensus CDS

CCDS84255.1

UniProtKB/TrEMBL

F6QF13, Q8BRT2

Related

ENSMUSP00000072107.7, ENSMUST00000072256.13

Conserved Domains (2) summary

cd06382
Location:38 → 416

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:431 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

87692789..88087751 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522919.5 → XP_006522982.1 glutamate receptor ionotropic, kainate 1 isoform X5

UniProtKB/TrEMBL

Q8BRT2

Conserved Domains (2) summary

cl10011
Location:40 → 289

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:304 → 673

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_036159782.1 → XP_036015675.1 glutamate receptor ionotropic, kainate 1 isoform X6

UniProtKB/TrEMBL

Q8BRT2

Conserved Domains (2) summary

cl10011
Location:40 → 274

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:289 → 658

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_006522920.4 → XP_006522983.1 glutamate receptor ionotropic, kainate 1 isoform X9

UniProtKB/TrEMBL

Q8BQZ0

Related

ENSMUST00000210910.2

Conserved Domains (2) summary

cd06382
Location:38 → 431

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:446 → 600

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily