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    Dock1 dedicator of cytokinesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 330662, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dock1provided by MGI
    Official Full Name
    dedicator of cytokinesis 1provided by MGI
    Primary source
    MGI:MGI:2429765
    See related
    Ensembl:ENSMUSG00000058325 AllianceGenome:MGI:2429765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b3190Clo; 9130006G06Rik; D630004B07Rik
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Is expressed in endocardial cushion and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.8), adrenal adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 79.14 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (134272416..134775376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134670687..135173647)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene inhibitory synaptic factor 2A Neighboring gene VISTA enhancer mm1401 Neighboring gene RIKEN cDNA 1700120G07 gene Neighboring gene STARR-seq mESC enhancer starr_20359 Neighboring gene predicted gene, 24581 Neighboring gene neuropeptide S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. Kiyokawa E, et al. J Biol Chem, 1998 Sep 18. PMID 9733740
    2. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1. Tajiri H, et al. Cell Rep, 2017 May 2. PMID 28467910
    3. Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling. Bagci H, et al. Cell Death Dis, 2014 Aug 14. PMID 25118935, Free PMC Article
    4. The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex. Sévajol M, et al. Biochimie, 2012 Mar. PMID 22177965
    5. Rac1 is essential for basement membrane-dependent epiblast survival. He X, et al. Mol Cell Biol, 2010 Jul. PMID 20457815, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
      Title: Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
    2. Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 coincide with a delay in the initiation of mammary gland involution.
      Title: Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.
    3. Dock1 and Dock5 are not the important exchange factors regulating Rac activity during the establishment and maintenance of the glomerular barrier
      Title: The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
    4. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis.
      Title: Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
    5. The phospholipase D-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.
      Title: Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.
    6. The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end.
      Title: The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.
    7. Results indicate that the combination of DOCK2 and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.
      Title: Role of DOCK2 and DOCK180 in fetal thymus colonization.
    8. Dock1 has an essential role in embryonic development.
      Title: The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 1
    Names
    180 kDa protein downstream of CRK
    DOCK180
    dedicator of cyto-kinesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033420.2 → NP_001028592.1  dedicator of cytokinesis protein 1

      See identical proteins and their annotated locations for NP_001028592.1

      Status: VALIDATED

      Source sequence(s)
      AC100208, AC127574, AC129300, AC136515, AC136641
      Consensus CDS
      CCDS40166.1
      UniProtKB/Swiss-Prot
      Q3URT8, Q3UY80, Q4QQL8, Q6PD14, Q8BUR4, Q8BVC9, Q91Z55, Q922V1
      Related
      ENSMUSP00000081531.5, ENSMUST00000084488.5
      Conserved Domains (4) summary
      cd08694
      Location:424 → 619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1214 → 1612
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      134272416..134775376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUR4.3 GenPept UniProtKB/Swiss-Prot:Q8BUR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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