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    Chrdl1 chordin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 83453, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Chrdl1provided by MGI
    Official Full Name
    chordin-like 1provided by MGI
    Primary source
    MGI:MGI:1933172
    See related
    Ensembl:ENSMUSG00000031283 AllianceGenome:MGI:1933172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHL; CHL1; VOPT; Nrln1
    Summary
    Acts upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and skeletal system. Human ortholog(s) of this gene implicated in megalocornea. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in genital fat pad adult (RPKM 5.5), bladder adult (RPKM 4.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F2; X 64.24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (142068670..142177282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (143285674..143394263, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene retrotransposon Gag like 9 Neighboring gene STARR-seq mESC enhancer starr_48027 Neighboring gene STARR-seq mESC enhancer starr_48028 Neighboring gene STARR-seq mESC enhancer starr_48029 Neighboring gene actin, beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_48030 Neighboring gene predicted gene, 23325 Neighboring gene STARR-seq mESC enhancer starr_48031 Neighboring gene p21 (RAC1) activated kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation. Ahn J, et al. Cells, 2023 Feb 15. PMID 36831292, Free PMC Article
    2. Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury. Blanco-Suarez E, et al. Sci Rep, 2022 Mar 9. PMID 35264691, Free PMC Article
    3. Ocular Manifestations of Chordin-like 1 Knockout Mice. Chen D, et al. Cornea, 2020 Sep. PMID 32452990, Free PMC Article
    4. Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells. Chandra A, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16630536
    5. Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3. Sun H, et al. Stem Cells, 2023 Apr 25. PMID 36682027

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.
      Title: Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.
    2. Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation.
      Title: Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation.
    3. Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury.
      Title: Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury.
    4. Ocular Manifestations of Chordin-like 1 Knockout Mice.
      Title: Ocular Manifestations of Chordin-like 1 Knockout Mice.
    5. study identified that astrocyte-secreted chordin-like 1 (Chrdl1) is necessary and sufficient to induce mature GluA2-containing synapses to form.
      Title: Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors.
    6. CHRDL-1 is a new regulatory target of miR-134 during cortical neuronal differentiation; this is a novel role for miR-134 in the modulation of cortical development.
      Title: Stage-specific modulation of cortical neuronal development by Mmu-miR-134.
    7. Reperfusion injury of proximal kidney tubules causes a reduction of Chrdl1 expression.
      Title: Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables BMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transforming growth factor beta binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in AMPA glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate determination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic axis specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in excitatory chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chordin-like protein 1
    Names
    neuralin-1
    neurogenesin-1
    ventroptin-alpha
    ventroptin-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114385.1 → NP_001107857.1  chordin-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001107857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF321853, AL713920, BX119959
      Consensus CDS
      CCDS53208.1
      UniProtKB/Swiss-Prot
      Q920C1, Q924K0, Q9EPZ9
      Related
      ENSMUSP00000108499.3, ENSMUST00000112878.9
      Conserved Domains (1) summary
      cl17735
      Location:110 → 173
      VWC; von Willebrand factor type C domain

    2. NM_001358592.1 → NP_001345521.1  chordin-like protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL713920, BX119959
      Conserved Domains (1) summary
      cl17735
      Location:111 → 174
      VWC; von Willebrand factor type C domain

    3. NM_031258.3 → NP_112548.2  chordin-like protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_112548.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF296451, AL713920, BX119959
      Consensus CDS
      CCDS30453.1
      UniProtKB/TrEMBL
      Q3TP73, Q6NXY0
      Related
      ENSMUSP00000074230.6, ENSMUST00000074660.12
      Conserved Domains (1) summary
      cl17735
      Location:110 → 173
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      142068670..142177282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529001.5 → XP_006529064.1  chordin-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl17735
      Location:111 → 174
      VWC; von Willebrand factor type C domain

    2. XM_006529002.5 → XP_006529065.1  chordin-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl17735
      Location:110 → 173
      VWC; von Willebrand factor type C domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920C1.1 GenPept UniProtKB/Swiss-Prot:Q920C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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