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    Trmt44 tRNA methyltransferase 44 [ Mus musculus (house mouse) ]

    Gene ID: 78890, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trmt44provided by MGI
    Official Full Name
    tRNA methyltransferase 44provided by MGI
    Primary source
    MGI:MGI:1926140
    See related
    Ensembl:ENSMUSG00000029097 AllianceGenome:MGI:1926140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mettl19; 2310079F23Rik
    Summary
    Predicted to enable tRNA (uracil) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in cytoplasm. Orthologous to human TRMT44 (tRNA methyltransferase 44 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 3.7), thymus adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt44 in Genome Data Viewer
    Location:
    5 B3; 5 18.25 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35713552..35732424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35556208..35575080, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40283 Neighboring gene STARR-seq mESC enhancer starr_12857 Neighboring gene carboxypeptidase Z Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene HtrA serine peptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (uridine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable tRNA (uracil-O(2)-)-methyltransferase
    Names
    methyltransferase-like protein 19
    NP_084484.2
    XP_006504256.1
    XP_036021511.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030208.3 → NP_084484.2  probable tRNA (uracil-O(2)-)-methyltransferase

      See identical proteins and their annotated locations for NP_084484.2

      Status: VALIDATED

      Source sequence(s)
      AC116705, AK132402
      Consensus CDS
      CCDS19230.1
      UniProtKB/Swiss-Prot
      A7MCV4, Q3V1K3, Q9D2Q2
      Related
      ENSMUSP00000030980.8, ENSMUST00000030980.12
      Conserved Domains (1) summary
      pfam07757
      Location:252 → 363
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35713552..35732424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165618.1 → XP_036021511.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X2

      Conserved Domains (1) summary
      pfam07757
      Location:3 → 90
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    2. XM_006504193.3 → XP_006504256.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam07757
      Location:80 → 191
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2Q2.2 GenPept UniProtKB/Swiss-Prot:Q9D2Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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