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    Pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [ Mus musculus (house mouse) ]

    Gene ID: 18705, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pik3c2gprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by MGI
    Primary source
    MGI:MGI:1203730
    See related
    Ensembl:ENSMUSG00000030228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C80387; PI3K-C2-gamma
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Expression
    Biased expression in kidney adult (RPKM 1.6), liver adult (RPKM 1.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Pik3c2g in Genome Data Viewer
    Location:
    6 G2; 6 69.7 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (139591070..139915010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (139614072..139969284)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (139562593..139605759) , (139664380..139917805)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RERG/RAS-like Neighboring gene RIKEN cDNA 4930404I20 gene Neighboring gene uncharacterized LOC118567412 Neighboring gene phospholipase C, zeta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
    Names
    phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
    ptdIns-3-kinase C2 subunit gamma
    NP_035214.2
    NP_997566.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011084.2NP_035214.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences, compared to variant 1, including the lack of multiple 5' coding exons. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC153381, AC159545
      Related
      ENSMUST00000189374.7
      Conserved Domains (3) summary
      cd06896
      Location:415515
      PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
      cd05177
      Location:33386
      PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
      cl14603
      Location:537649
      C2; C2 domain
    2. NM_207683.3NP_997566.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB008791, AC122511, AC153381, AC159545, AC174651, AK076317
      Conserved Domains (5) summary
      cd06896
      Location:12681368
      PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:538698
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd05177
      Location:8861239
      PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
      cl00271
      Location:713880
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl14603
      Location:13901502
      C2; C2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      139591070..139915010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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