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    Odf2l outer dense fiber of sperm tails 2-like [ Mus musculus (house mouse) ]

    Gene ID: 52184, updated on 31-Mar-2024

    Summary

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    Official Symbol
    Odf2lprovided by MGI
    Official Full Name
    outer dense fiber of sperm tails 2-likeprovided by MGI
    Primary source
    MGI:MGI:1098600
    See related
    Ensembl:ENSMUSG00000028256 AllianceGenome:MGI:1098600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Ertd250e; 4733401D09Rik; 9630045K08Rik
    Summary
    Involved in negative regulation of cilium assembly. Predicted to be located in centriolar satellite. Predicted to be active in centrosome and ciliary basal body. Orthologous to human ODF2L (outer dense fiber of sperm tails 2 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.7), CNS E14 (RPKM 2.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 H2; 3 69.36 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144824330..144859676)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145118569..145153915)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09190 Neighboring gene STARR-seq mESC enhancer starr_09191 Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene chloride channel accessory 2 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144794197-144794498 Neighboring gene predicted gene, 40163 Neighboring gene collagen, type XXIV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_09192 Neighboring gene predicted gene, 35133 Neighboring gene STARR-seq mESC enhancer starr_09193 Neighboring gene STARR-seq mESC enhancer starr_09194 Neighboring gene STARR-seq mESC enhancer starr_09195 Neighboring gene STARR-seq mESC enhancer starr_09196 Neighboring gene STARR-seq mESC enhancer starr_09197 Neighboring gene zinc finger, HIT type 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. de Saram P, et al. J Cell Sci, 2017 Oct 1. PMID 28775150
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein BCAP
    Names
    basal body centriole-associated protein
    outer dense fiber protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162538.2 → NP_001156010.1  protein BCAP isoform 1

      See identical proteins and their annotated locations for NP_001156010.1

      Status: VALIDATED

      Source sequence(s)
      AC152400
      Consensus CDS
      CCDS51087.1
      UniProtKB/Swiss-Prot
      Q8CD32, Q8VDY5, Q9D478, Q9D647
      Related
      ENSMUSP00000096140.3, ENSMUST00000098538.9
      Conserved Domains (2) summary
      pfam01496
      Location:325 → 382
      V_ATPase_I; V-type ATPase 116kDa subunit family
      cl19511
      Location:480 → 603
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

    2. NM_001162539.2 → NP_001156011.1  protein BCAP isoform 3

      See identical proteins and their annotated locations for NP_001156011.1

      Status: VALIDATED

      Source sequence(s)
      AC152400
      Consensus CDS
      CCDS51088.1
      UniProtKB/Swiss-Prot
      Q9D478
      Related
      ENSMUSP00000029920.9, ENSMUST00000029920.15
      Conserved Domains (2) summary
      COG1196
      Location:241 → 494
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:84 → 349
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001428793.1 → NP_001415722.1  protein BCAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152400

    4. NM_001428794.1 → NP_001415723.1  protein BCAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152400

    5. NM_001428795.1 → NP_001415724.1  protein BCAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152400

    6. NM_001428796.1 → NP_001415725.1  protein BCAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152400

    7. NM_001428797.1 → NP_001415726.1  protein BCAP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152400

    8. NM_001428798.1 → NP_001415727.1  protein BCAP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152400

    9. NM_025714.5 → NP_079990.2  protein BCAP isoform 2

      See identical proteins and their annotated locations for NP_079990.2

      Status: VALIDATED

      Source sequence(s)
      AC152400
      Consensus CDS
      CCDS17891.1
      UniProtKB/Swiss-Prot
      Q9D478
      Related
      ENSMUSP00000096141.3, ENSMUST00000098539.7
      Conserved Domains (2) summary
      COG1196
      Location:284 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144824330..144859676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252679.1 → XP_030108539.1  protein BCAP isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:284 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006501678.4 → XP_006501741.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501741.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_030252680.1 → XP_030108540.1  protein BCAP isoform X4

      Related
      ENSMUSP00000101798.3, ENSMUST00000106192.9
      Conserved Domains (2) summary
      COG1196
      Location:284 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006501675.4 → XP_006501738.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501738.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_030252678.2 → XP_030108538.1  protein BCAP isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:284 → 563
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_030252677.1 → XP_030108537.1  protein BCAP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:90 → 611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_036163160.1 → XP_036019053.1  protein BCAP isoform X7

      Conserved Domains (1) summary
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_030252683.2 → XP_030108543.1  protein BCAP isoform X8

      Conserved Domains (1) summary
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_030252676.2 → XP_030108536.1  protein BCAP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:90 → 611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_036163161.1 → XP_036019054.1  protein BCAP isoform X9

      Conserved Domains (1) summary
      COG1196
      Location:67 → 370
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_036163158.1 → XP_036019051.1  protein BCAP isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:241 → 494
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:84 → 349
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_006501681.3 → XP_006501744.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501744.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. XM_036163155.1 → XP_036019048.1  protein BCAP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:90 → 611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_036163159.1 → XP_036019052.1  protein BCAP isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:241 → 494
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:84 → 349
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_030252682.2 → XP_030108542.1  protein BCAP isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:241 → 494
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:84 → 349
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_006501676.5 → XP_006501739.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501739.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    17. XM_036163157.1 → XP_036019050.1  protein BCAP isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:284 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    18. XM_006501677.5 → XP_006501740.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501740.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. XM_006501680.5 → XP_006501743.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501743.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    20. XM_030252681.2 → XP_030108541.1  protein BCAP isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:284 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:127 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    21. XM_006501683.4 → XP_006501746.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501746.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    22. XM_006501682.3 → XP_006501745.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_006501745.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    23. XM_036163156.1 → XP_036019049.1  protein BCAP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:90 → 611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    24. XM_011240157.4 → XP_011238459.1  protein BCAP isoform X1

      See identical proteins and their annotated locations for XP_011238459.1

      Conserved Domains (2) summary
      PRK02224
      Location:247 → 655
      PRK02224; DNA double-strand break repair Rad50 ATPase
      COG1196
      Location:89 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    25. XM_017319643.1 → XP_017175132.1  protein BCAP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:90 → 611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    26. XM_006501688.4 → XP_006501751.1  protein BCAP isoform X6

      Conserved Domains (1) summary
      PRK02224
      Location:73 → 481
      PRK02224; DNA double-strand break repair Rad50 ATPase

    RNA

    1. XR_004941360.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D478.1 GenPept UniProtKB/Swiss-Prot:Q9D478

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