Uox urate oxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uoxprovided by MGI
Official Full Name: urate oxidaseprovided by MGI
Primary source: MGI:MGI:98907
See related: Ensembl:ENSMUSG00000028186 AllianceGenome:MGI:98907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables urate oxidase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic process. Located in mitochondrion. Is active in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Used to study hyperuricemia; kidney disease; and nephrogenic diabetes insipidus. Orthologous to human UOX (urate oxidase (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 291.5) and liver adult (RPKM 169.5) See more
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Genomic context

Location:: 3 H2; 3 72.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146302904..146337238)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146597149..146631483)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy.
Title: A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy.
Uricase knockout provides a suitable mouse model to investigate hyperuricemia and associated disorders mimicking the human condition, suggesting that hyperuricemia has a causal role in the development of metabolic disorders and hypertension.
Title: Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.
Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.
Title: Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.
Urate oxidase knockout mice have increased concentrations of brain urate, which plays a neuroprotective role in dopaminergic neurons.
Title: Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.
gene lie head-to-head with the DLAD gene
Title: Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Radiation induced (1) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Markers

UOX (e-PCR)
- UniSTS:264969

Uox (e-PCR), detects polymorphism
- UniSTS:507304

AI663847 (e-PCR)
- UniSTS:165305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables urate oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables urate oxidase activity	ISO Inferred from Sequence Orthology more info
enables urate oxidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in IMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in allantoin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dAMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyadenosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyguanosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyinosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in guanine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hypoxanthine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine nucleobase metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in urate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xanthine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: uricase

NP_033500.1

EC 1.7.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009474.5 → NP_033500.1 uricase

See identical proteins and their annotated locations for NP_033500.1

Status: PROVISIONAL

Source sequence(s)

AC141632

Consensus CDS

CCDS17905.1

UniProtKB/Swiss-Prot

P25688

UniProtKB/TrEMBL

Q543J0, Q8C7K4

Related

ENSMUSP00000029837.8, ENSMUST00000029837.14

Conserved Domains (2) summary

cd00445
Location:20 → 297

Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...

TIGR03383
Location:15 → 297

urate_oxi; urate oxidase