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    Aopep aminopeptidase O [ Mus musculus (house mouse) ]

    Gene ID: 72061, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aopepprovided by MGI
    Official Full Name
    aminopeptidase Oprovided by MGI
    Primary source
    MGI:MGI:1919311
    See related
    Ensembl:ENSMUSG00000021458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ApO; AP-O; mir-23b; mir-27b; AW742919; mir-24-1; 2010111I01Rik; 2300006M17Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.3), limb E14.5 (RPKM 9.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Aopep in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63112707..63473910)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62964893..63326096)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (63116294..63400964)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38679 Neighboring gene fructose bisphosphatase 1 Neighboring gene predicted gene, 40981 Neighboring gene tubulin, beta 2a, pseudogene 1 Neighboring gene predicted gene, 46422 Neighboring gene predicted gene, 30409 Neighboring gene microRNA 3074-1 Neighboring gene predicted gene, 16907 Neighboring gene microRNA 24-1 Neighboring gene microRNA 23b Neighboring gene microRNA 27b Neighboring gene Fanconi anemia, complementation group C Neighboring gene Ptch1 Hedgehog-responsive enhancers Neighboring gene patched 1 Neighboring gene predicted gene, 30655

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289924.1NP_001276853.1  aminopeptidase O

      See identical proteins and their annotated locations for NP_001276853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154382, AK044477, CT009757
      Consensus CDS
      CCDS36699.1
      UniProtKB/Swiss-Prot
      Q8BXQ6
      UniProtKB/TrEMBL
      Q3UQZ7
      Related
      ENSMUSP00000152528.2, ENSMUST00000220863.2
      Conserved Domains (2) summary
      pfam09127
      Location:680821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:186634
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    2. NM_001289926.1NP_001276855.1  aminopeptidase O

      See identical proteins and their annotated locations for NP_001276855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 3' UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK044477, AK141931, BX520155, CT009757
      Consensus CDS
      CCDS36699.1
      UniProtKB/Swiss-Prot
      Q8BXQ6
      UniProtKB/TrEMBL
      Q3UQZ7
      Related
      ENSMUSP00000089148.5, ENSMUST00000091560.11
      Conserved Domains (2) summary
      pfam09127
      Location:680821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:186634
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RNA

    1. NR_110520.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      CT009757
    2. NR_110521.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' and 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC130827, AK076298, CT009757
      Related
      ENSMUST00000159152.3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      63112707..63473910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028079.2: Suppressed sequence

      Description
      NM_028079.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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