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    Ankar ankyrin and armadillo repeat containing [ Mus musculus (house mouse) ]

    Gene ID: 319695, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankarprovided by MGI
    Official Full Name
    ankyrin and armadillo repeat containingprovided by MGI
    Primary source
    MGI:MGI:2442559
    See related
    Ensembl:ENSMUSG00000039342 AllianceGenome:MGI:2442559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932422E22Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human ANKAR (ankyrin and armadillo repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 7.7) See more
    Orthologs
    human all
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    Genomic context

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    See Ankar in Genome Data Viewer
    Location:
    1 C3; 1 36.8 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72682139..72739743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72642980..72700584, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 4 Neighboring gene SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1548 Neighboring gene STARR-seq mESC enhancer starr_01281 Neighboring gene predicted gene, 39662 Neighboring gene STARR-seq mESC enhancer starr_01283 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene ribosomal protein L37a Neighboring gene predicted gene, 51632 Neighboring gene predicted gene, 39663

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel human gene containing ANK repeats and ARM domains. Occhi G, et al. Biochem Biophys Res Commun, 2004 May 21. PMID 15110750
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin and armadillo repeat-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347063.1 → NP_001333992.1  ankyrin and armadillo repeat-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121498, AC163484
      Consensus CDS
      CCDS83554.1
      UniProtKB/TrEMBL
      A0A1D5RM61, B7ZNI2
      Related
      ENSMUSP00000148801.2, ENSMUST00000211837.2

    2. NM_176980.4 → NP_795954.2  ankyrin and armadillo repeat-containing protein isoform 1

      See identical proteins and their annotated locations for NP_795954.2

      Status: VALIDATED

      Source sequence(s)
      AK030065, AK077036, BC132415
      Consensus CDS
      CCDS15035.1
      UniProtKB/Swiss-Prot
      A2RT91, Q8C0Q1
      UniProtKB/TrEMBL
      A0A1D5RM61
      Related
      ENSMUSP00000054056.5, ENSMUST00000053499.6
      Conserved Domains (5) summary
      cd00020
      Location:751 → 864
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00204
      Location:581 → 705
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:587 → 682
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:582 → 613
      ANK; ANK repeat [structural motif]
      sd00043
      Location:750 → 782
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72682139..72739743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496060.3 → XP_006496123.1  ankyrin and armadillo repeat-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A1D5RM61
      Conserved Domains (6) summary
      PLN03200
      Location:705 → 973
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:870 → 1116
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00045
      Location:602 → 636
      ANK; ANK repeat [structural motif]
      sd00043
      Location:737 → 769
      ARM; armadillo repeat [structural motif]
      pfam12796
      Location:574 → 669
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:526 → 599
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_017321180.2 → XP_017176669.1  ankyrin and armadillo repeat-containing protein isoform X2

      Conserved Domains (5) summary
      PLN03200
      Location:223 → 491
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:388 → 634
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00045
      Location:87 → 118
      ANK; ANK repeat [structural motif]
      sd00043
      Location:255 → 287
      ARM; armadillo repeat [structural motif]
      pfam12796
      Location:92 → 187
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_003955720.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RT91.1 GenPept UniProtKB/Swiss-Prot:A2RT91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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