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    Tspan17 tetraspanin 17 [ Mus musculus (house mouse) ]

    Gene ID: 74257, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tspan17provided by MGI
    Official Full Name
    tetraspanin 17provided by MGI
    Primary source
    MGI:MGI:1921507
    See related
    Ensembl:ENSMUSG00000025875 AllianceGenome:MGI:1921507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbxo23; Tm4sf17; 2210021G21Rik
    Summary
    Enables enzyme binding activity. Involved in protein maturation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; ganglia; neural retina; and ventral grey horn. Orthologous to human TSPAN17 (tetraspanin 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), cerebellum adult (RPKM 14.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan17 in Genome Data Viewer
    Location:
    13 B1; 13 29.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54936915..54944588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54789102..54796775)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene predicted gene, 40959 Neighboring gene predicted gene, 31188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Mearini G, et al. Cardiovasc Res, 2010 Jan 15. PMID 19850579, Free PMC Article
    2. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
    3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-17
    Names
    F-box only protein 23
    tetraspan protein SB134
    transmembrane 4 superfamily member 17
    tspan-17
    NP_083117.2
    XP_006517477.1
    XP_006517478.1
    XP_006517480.1
    XP_017171106.1
    XP_017171107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028841.3 → NP_083117.2  tetraspanin-17

      See identical proteins and their annotated locations for NP_083117.2

      Status: VALIDATED

      Source sequence(s)
      AI019499, AK008761, BY734818, CD740983
      Consensus CDS
      CCDS26536.1
      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      UniProtKB/TrEMBL
      Q3TAQ3
      Related
      ENSMUSP00000026993.8, ENSMUST00000026993.14
      Conserved Domains (2) summary
      cd03159
      Location:115 → 235
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:16 → 263
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54936915..54944588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517414.3 → XP_006517477.1  tetraspanin-17 isoform X1

      See identical proteins and their annotated locations for XP_006517477.1

      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      Related
      ENSMUSP00000115287.3, ENSMUST00000131692.9
      Conserved Domains (1) summary
      cd03159
      Location:115 → 235
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. XM_006517415.3 → XP_006517478.1  tetraspanin-17 isoform X2

      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      Conserved Domains (2) summary
      cd03159
      Location:115 → 210
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18 → 191
      Tetraspannin; Tetraspanin family

    3. XM_017315617.2 → XP_017171106.1  tetraspanin-17 isoform X3

      UniProtKB/TrEMBL
      F6VW20
      Related
      ENSMUSP00000123607.3, ENSMUST00000130568.9
      Conserved Domains (2) summary
      cd03159
      Location:115 → 194
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18 → 191
      Tetraspannin; Tetraspanin family

    4. XM_006517417.4 → XP_006517480.1  tetraspanin-17 isoform X5

      Conserved Domains (2) summary
      cl02781
      Location:115 → 194
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:18 → 191
      Tetraspannin; Tetraspanin family

    5. XM_017315618.2 → XP_017171107.1  tetraspanin-17 isoform X4

      UniProtKB/TrEMBL
      E9PWC3
      Related
      ENSMUSP00000131671.2, ENSMUST00000163796.8
      Conserved Domains (1) summary
      cd03159
      Location:49 → 169
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    RNA

    1. XR_382461.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7W4.1 GenPept UniProtKB/Swiss-Prot:Q9D7W4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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