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    Bmerb1 bMERB domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67254, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bmerb1provided by MGI
    Official Full Name
    bMERB domain containing 1provided by MGI
    Primary source
    MGI:MGI:1914504
    See related
    Ensembl:ENSMUSG00000044117 AllianceGenome:MGI:1914504
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MINP; 2900011O08Rik
    Summary
    Acts upstream of or within negative regulation of cell motility involved in cerebral cortex radial glia guided migration and negative regulation of microtubule depolymerization. Located in microtubule cytoskeleton. Is expressed in several structures, including central nervous system; colon; cornea stroma; glans of male genital tubercle; and peripheral nervous system ganglion. Orthologous to human BMERB1 (bMERB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 22.3), CNS E18 (RPKM 21.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bmerb1 in Genome Data Viewer
    Location:
    16 A1; 16 9.66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13802975..13922916)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13986612..14105052)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40163 Neighboring gene STARR-positive B cell enhancer ABC_E8619 Neighboring gene Mpv17 transgene, kidney disease mutant-like Neighboring gene STARR-seq mESC enhancer starr_40164 Neighboring gene laminin, gamma 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40165 Neighboring gene STARR-seq mESC enhancer starr_40166 Neighboring gene STARR-seq mESC enhancer starr_40168 Neighboring gene STARR-seq mESC enhancer starr_40169 Neighboring gene STARR-seq mESC enhancer starr_40170 Neighboring gene interferon induced transmembrane protein 7 Neighboring gene STARR-seq mESC enhancer starr_40172 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like Neighboring gene Y box protein 1 pseudogene Neighboring gene meiosis regulator and mRNA stability 1 Neighboring gene STARR-positive B cell enhancer ABC_E7428 Neighboring gene microRNA 484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Zhang S, et al. Sci Rep, 2014 Aug 7. PMID 25099998, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The newly identified migration inhibitory protein (MINP) regulates the radial migration in the developing neocortex.
      Title: The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of cell motility involved in cerebral cortex radial glia guided migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell motility involved in cerebral cortex radial glia guided migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bMERB domain-containing protein 1
    Names
    migration inhibitory protein
    uncharacterized protein C16orf45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144518.3 → NP_653101.1  bMERB domain-containing protein 1

      See identical proteins and their annotated locations for NP_653101.1

      Status: PROVISIONAL

      Source sequence(s)
      AK136859
      Consensus CDS
      CCDS27971.1
      UniProtKB/Swiss-Prot
      Q3UVX0, Q8R1Y2
      Related
      ENSMUSP00000062758.6, ENSMUST00000056521.12
      Conserved Domains (1) summary
      cl23748
      Location:63 → 142
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      13802975..13922916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160096.1 → XP_036015989.1  bMERB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVX0, Q8R1Y2
      Conserved Domains (1) summary
      cl23748
      Location:63 → 142
      DUF3585; Protein of unknown function (DUF3585)

    2. XM_006522482.4 → XP_006522545.1  bMERB domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl23748
      Location:9 → 79
      DUF3585; Protein of unknown function (DUF3585)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1Y2.1 GenPept UniProtKB/Swiss-Prot:Q8R1Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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