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    Evi2a ecotropic viral integration site 2a [ Mus musculus (house mouse) ]

    Gene ID: 14017, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Evi2aprovided by MGI
    Official Full Name
    ecotropic viral integration site 2aprovided by MGI
    Primary source
    MGI:MGI:95458
    See related
    Ensembl:ENSMUSG00000078771 AllianceGenome:MGI:95458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi2; Evi-2
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in thymus primordium and ureter. Orthologous to human EVI2A (ecotropic viral integration site 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 10.5), spleen adult (RPKM 8.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Evi2a in Genome Data Viewer
    Location:
    11 B5; 11 46.81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79417386..79421435, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79526560..79530609, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2b Neighboring gene ecotropic viral integration site 2 Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II) Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79428461-79428644 Neighboring gene predicted gene, 23293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. Largaespada DA, et al. J Virol, 1995 Aug. PMID 7609078, Free PMC Article
    2. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. Cho BC, et al. J Virol, 1995 Nov. PMID 7474134, Free PMC Article
    3. Evi-2, a common integration site involved in murine myeloid leukemogenesis. Buchberg AM, et al. Mol Cell Biol, 1990 Sep. PMID 2167436, Free PMC Article
    4. Function of 14-3-3 proteins. Jin DY, et al. Nature, 1996 Jul 25. PMID 8684458
    5. The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1. Kurtz A, et al. Mamm Genome, 1995 Feb. PMID 7767001

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Evi2

    Readthrough gene: Evi2, Included gene: Evi2b

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein EVI2A
    Names
    EVI-2A
    ecotropic viral integration site 2A protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033711.1 → NP_001028883.1  protein EVI2A precursor

      See identical proteins and their annotated locations for NP_001028883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL591174, BC038124
      Consensus CDS
      CCDS25122.1
      UniProtKB/Swiss-Prot
      P20934, Q6DKP1
      UniProtKB/TrEMBL
      Q3TBB7
      Related
      ENSMUSP00000159581.1, ENSMUST00000133148.3
      Conserved Domains (1) summary
      pfam05399
      Location:1 → 223
      EVI2A; Ectropic viral integration site 2A protein (EVI2A)

    2. NM_010161.3 → NP_034291.1  protein EVI2A precursor

      See identical proteins and their annotated locations for NP_034291.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL591174, BC038124
      Consensus CDS
      CCDS25122.1
      UniProtKB/Swiss-Prot
      P20934, Q6DKP1
      UniProtKB/TrEMBL
      Q3TBB7
      Related
      ENSMUSP00000099526.4, ENSMUST00000103236.4
      Conserved Domains (1) summary
      pfam05399
      Location:1 → 223
      EVI2A; Ectropic viral integration site 2A protein (EVI2A)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79417386..79421435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20934.2 GenPept UniProtKB/Swiss-Prot:P20934

    Gene LinkOut

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