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    Vpreb1b V-set pre-B cell surrogate light chain 1B [ Mus musculus (house mouse) ]

    Gene ID: 22363, updated on 14-May-2024

    Summary

    Official Symbol
    Vpreb1bprovided by MGI
    Official Full Name
    V-set pre-B cell surrogate light chain 1Bprovided by MGI
    Primary source
    MGI:MGI:98937
    See related
    Ensembl:ENSMUSG00000059280 AllianceGenome:MGI:98937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD179b; VpreB1; Vpreb2; Vpreb-2
    Summary
    Acts upstream of or within several processes, including B cell proliferation; homeostasis of number of cells; and regulation of cell size. Predicted to be active in extracellular space. Is expressed in bone marrow; liver; and spleen. Orthologous to human VPREB1 (V-set pre-B cell surrogate light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 2.4), thymus adult (RPKM 0.3) and 4 other tissues See more
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    Genomic context

    See Vpreb1b in Genome Data Viewer
    Location:
    16 A3; 16 11.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17797314..17799138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17979445..17981274)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40267 Neighboring gene solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 Neighboring gene predicted gene, 41427 Neighboring gene STARR-seq mESC enhancer starr_40270 Neighboring gene STARR-seq mESC enhancer starr_40272 Neighboring gene STARR-seq mESC enhancer starr_40274 Neighboring gene predicted gene, 49580 Neighboring gene DiGeorge syndrome critical region gene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    immunoglobulin omega chain
    Names
    Lambda 5
    pre-B lymphocyte gene 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016983.1NP_058679.1  immunoglobulin omega chain precursor

      See identical proteins and their annotated locations for NP_058679.1

      Status: VALIDATED

      Source sequence(s)
      X05563
      Consensus CDS
      CCDS28015.1
      UniProtKB/Swiss-Prot
      P13373
      UniProtKB/TrEMBL
      Q0VEN0
      Related
      ENSMUSP00000074835.4, ENSMUST00000075371.5
      Conserved Domains (2) summary
      smart00410
      Location:26125
      IG_like; Immunoglobulin like
      cl11960
      Location:29118
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17797314..17799138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316944.3XP_017172433.1  immunoglobulin omega chain isoform X1

      UniProtKB/TrEMBL
      Q0VEN0
      Conserved Domains (1) summary
      cl11960
      Location:58147
      Ig; Immunoglobulin domain
    2. XM_017316945.2XP_017172434.1  immunoglobulin omega chain isoform X1

      UniProtKB/TrEMBL
      Q0VEN0
      Conserved Domains (1) summary
      cl11960
      Location:58147
      Ig; Immunoglobulin domain