Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb2provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 2provided by MGI
Primary source: MGI:MGI:97609
See related: Ensembl:ENSMUSG00000062345 AllianceGenome:MGI:97609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAI-2; Planh2; ovalbumin
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and wound healing. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; immune system; mesothelium; respiratory system; and skin. Orthologous to human SERPINB2 (serpin family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 1.2), liver E14.5 (RPKM 1.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (107439153..107453330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (107500892..107525600)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model.
Title: Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model.
SerpinB2 Regulates Immune Response in Kidney Injury and Aging.
Title: SerpinB2 Regulates Immune Response in Kidney Injury and Aging.
SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
Title: SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
Stem cell senescence may enhance SERPINB2 expression, which in turn mediates the effect of SHH on alleviating senescence-induced endometrial stem cell dysfunctions, suggesting that SERPINB2 is a master regulator of SHH signaling during the aging process.
Title: An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2.
although SerpinB2 has classically been associated with inhibition of uPA-mediated fibrinolysis, we illustrate herein that SerpinB2 (at least in mice) has an unexpected platelet-associated activity in the regulation clot formation.
Title: SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation.
The observed reduction of the infarct volume was comparable to the protection obtained by intracerebroventricular injection of recombinant Activin A or SerpinB2 or by stereotactic delivery 3 weeks prior to the injury of a recombinant adeno-associated virus containing an expression cassette for the potent neuroprotective transcription factor Npas4
Title: Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model.
This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling
Title: SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation
Title: SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents.
SerpinB2 plays an important role in proteostas
Title: SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.
PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA activity mechanisms, distinct from PAI-1
Title: Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Serpinb2 (e-PCR), detects polymorphism
- UniSTS:144214

PMC15197P1 (e-PCR)
- UniSTS:271195

PMC15197P2 (e-PCR)
- UniSTS:271196

Serpinb2 (e-PCR), detects polymorphism
- UniSTS:525940

8STS01 (e-PCR)
- UniSTS:504272

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plasminogen activator inhibitor 2, macrophage

Names: plasminogen activator inhibitor, type II; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; serine (or cysteine) proteinase inhibitor, clade B, member 2; serpin B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001174170.1 → NP_001167641.1 plasminogen activator inhibitor 2, macrophage

See identical proteins and their annotated locations for NP_001167641.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AI847983, AK081487

Consensus CDS

CCDS15219.1

UniProtKB/Swiss-Prot

O35687, P12388, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6

UniProtKB/TrEMBL

Q542A3

Related

ENSMUSP00000009356.5, ENSMUST00000009356.11

Conserved Domains (1) summary

cl00137
Location:4 → 415

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_011111.4 → NP_035241.1 plasminogen activator inhibitor 2, macrophage

See identical proteins and their annotated locations for NP_035241.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AI847983, AK090049, BY195599

Consensus CDS

CCDS15219.1

UniProtKB/Swiss-Prot

O35687, P12388, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6

UniProtKB/TrEMBL

Q542A3

Related

ENSMUSP00000065277.3, ENSMUST00000064916.9

Conserved Domains (1) summary

cl00137
Location:4 → 415

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...