Usp22 ubiquitin specific peptidase 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp22provided by MGI
Official Full Name: ubiquitin specific peptidase 22provided by MGI
Primary source: MGI:MGI:2144157
See related: Ensembl:ENSMUSG00000042506 AllianceGenome:MGI:2144157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in nucleus. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 112.1), whole brain E14.5 (RPKM 101.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61042607..61065885, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61151781..61175059, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
Title: USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway.
Title: USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway.
Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-alpha-TAK1 signaling pathway.
Title: Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-α-TAK1 signaling pathway.
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Title: USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Usp22 is an intracellular regulator of systemic emergency hematopoiesis.
Title: Usp22 is an intracellular regulator of systemic emergency hematopoiesis.
Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury.
Title: Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury.
USP22 promotes proinflammatory responses in Pseudomonas aeruginosainduced keratitis by targeting TRAF6.
Title: USP22 promotes pro‑inflammatory responses in Pseudomonas aeruginosa‑induced keratitis by targeting TRAF6.
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Title: USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization.
Title: Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization.
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Title: USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236595

Usp22 (e-PCR), detects polymorphism
- UniSTS:516160

AI427806 (e-PCR)
- UniSTS:165761

Usp22 (e-PCR), detects polymorphism
- UniSTS:480429

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H2A deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2B deubiquitinase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 22

Names: deubiquitinating enzyme 22; ubiquitin specific protease 22; ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific-processing protease 22

NP_001004143.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004143.4 → NP_001004143.2 ubiquitin carboxyl-terminal hydrolase 22

See identical proteins and their annotated locations for NP_001004143.2

Status: VALIDATED

Source sequence(s)

AK160992, AL646093

Consensus CDS

CCDS24807.1

UniProtKB/Swiss-Prot

Q3TU34, Q3U2W4, Q5DU02, Q5SU81, Q66JV8, Q6PDX3, Q8BJG3

Related

ENSMUSP00000041263.9, ENSMUST00000041683.9

Conserved Domains (2) summary

cd02660
Location:176 → 518

Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam02148
Location:63 → 123

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein