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    Sult2a8 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 76971, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Sult2a8provided by MGI
    Official Full Name
    sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8provided by MGI
    Primary source
    MGI:MGI:1924221
    See related
    Ensembl:ENSMUSG00000030378 AllianceGenome:MGI:1924221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L-STL; mL-STL; 2810007J24Rik
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Involved in bile acid catabolic process. Located in cytosol. Is expressed in liver and olfactory epithelium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver adult (RPKM 19.7) See more
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    Genomic context

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    See Sult2a8 in Genome Data Viewer
    Location:
    7 A1; 7 8.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (14144611..14180705, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (14410686..14446780, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20, pseudogene Neighboring gene mitochondrial ribosomal protein S36, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_18100 Neighboring gene STARR-seq mESC enhancer starr_18101 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 7 Neighboring gene oocyte specific homeobox 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation. Teramoto T, et al. Biochem Biophys Res Commun, 2021 Jul 12. PMID 34030040
    2. Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids. Wang K, et al. J Lipid Res, 2021. PMID 33872606, Free PMC Article
    3. Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice. Wang K, et al. Transgenic Res, 2020 Dec. PMID 33029720
    4. The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Shimohira T, et al. Biosci Biotechnol Biochem, 2018 Aug. PMID 29685090
    5. Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). Feng L, et al. J Lipid Res, 2017 Jun. PMID 28442498, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice.
      Title: Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice.
    2. The crystal structure of mouse SULT2A8 reveals the mechanism of 7alpha-hydroxyl, bile acid sulfation.
      Title: The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation.
    3. findings suggested that substitutions of two amino acids, which might have occurred during the evolution of the mouse SULT2A8 gene, endowed mouse SULT2A8 the capacity to catalyze the 7-O-sulfation of bile acids
      Title: The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids.
    4. a novel PPARalpha-dependent gene
      Title: Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile-salt sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycochenodeoxycholate sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 2A8
    Names
    glycochenodeoxycholate sulfotransferase 2A8
    liver sulfotransferase-like protein
    sulfotransferase-like protein 1
    NP_001186235.1
    NP_780459.1
    XP_006540489.1
    XP_006540490.1
    XP_006540491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199306.1 → NP_001186235.1  sulfotransferase 2A8

      See identical proteins and their annotated locations for NP_001186235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110880, AK050422
      Consensus CDS
      CCDS20833.1
      UniProtKB/Swiss-Prot
      B1PQU4, Q8BGL3
      UniProtKB/TrEMBL
      Q8K0B9
      Related
      ENSMUSP00000128428.3, ENSMUST00000168252.9
      Conserved Domains (1) summary
      pfam00685
      Location:34 → 275
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_175250.5 → NP_780459.1  sulfotransferase 2A8

      See identical proteins and their annotated locations for NP_780459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110880, AK041070
      Consensus CDS
      CCDS20833.1
      UniProtKB/Swiss-Prot
      B1PQU4, Q8BGL3
      UniProtKB/TrEMBL
      Q8K0B9
      Related
      ENSMUSP00000066897.5, ENSMUST00000063509.11
      Conserved Domains (1) summary
      pfam00685
      Location:34 → 275
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      14144611..14180705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540426.2 → XP_006540489.1  sulfotransferase 2A8 isoform X1

      See identical proteins and their annotated locations for XP_006540489.1

      UniProtKB/Swiss-Prot
      B1PQU4, Q8BGL3
      UniProtKB/TrEMBL
      Q8K0B9
      Conserved Domains (1) summary
      pfam00685
      Location:34 → 275
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_006540427.2 → XP_006540490.1  sulfotransferase 2A8 isoform X1

      See identical proteins and their annotated locations for XP_006540490.1

      UniProtKB/Swiss-Prot
      B1PQU4, Q8BGL3
      UniProtKB/TrEMBL
      Q8K0B9
      Conserved Domains (1) summary
      pfam00685
      Location:34 → 275
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_006540428.1 → XP_006540491.1  sulfotransferase 2A8 isoform X1

      See identical proteins and their annotated locations for XP_006540491.1

      UniProtKB/Swiss-Prot
      B1PQU4, Q8BGL3
      UniProtKB/TrEMBL
      Q8K0B9
      Conserved Domains (1) summary
      pfam00685
      Location:34 → 275
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGL3.1 GenPept UniProtKB/Swiss-Prot:Q8BGL3

    Gene LinkOut

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