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    Adam30 a disintegrin and metallopeptidase domain 30 [ Mus musculus (house mouse) ]

    Gene ID: 71078, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Adam30provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 30provided by MGI
    Primary source
    MGI:MGI:1918328
    See related
    Ensembl:ENSMUSG00000043468 AllianceGenome:MGI:1918328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    svph4; 4933424D07Rik
    Summary
    Located in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM30 (ADAM metallopeptidase domain 30). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 42.63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98067950..98071485)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98160634..98164169)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97737302-97737411 Neighboring gene VISTA enhancer mm576 Neighboring gene predicted gene 5544 Neighboring gene STARR-positive B cell enhancer ABC_E6087 Neighboring gene STARR-positive B cell enhancer ABC_E3453 Neighboring gene notch 2 Neighboring gene predicted gene, 40103 Neighboring gene STARR-seq mESC enhancer starr_08478 Neighboring gene STARR-positive B cell enhancer mm9_chr3:97961638-97961939 Neighboring gene RNA binding motif protein, X chromosome pseudogene Neighboring gene predicted gene, 40104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    2. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
    3. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC132801, MGC132802, 4933424D07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 30
    Names
    a disintegrin and metalloproteinase domain 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027665.2 → NP_081941.1  disintegrin and metalloproteinase domain-containing protein 30 precursor

      See identical proteins and their annotated locations for NP_081941.1

      Status: VALIDATED

      Source sequence(s)
      AK077058, BB615407
      Consensus CDS
      CCDS17660.1
      UniProtKB/TrEMBL
      Q811Q3
      Related
      ENSMUSP00000060505.4, ENSMUST00000050342.5
      Conserved Domains (5) summary
      smart00608
      Location:483 → 624
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:202 → 391
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:407 → 479
      Disintegrin; Disintegrin
      pfam01421
      Location:202 → 393
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:58 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      98067950..98071485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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