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    Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [ Mus musculus (house mouse) ]

    Gene ID: 27226, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pla2g7provided by MGI
    Official Full Name
    phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)provided by MGI
    Primary source
    MGI:MGI:1351327
    See related
    Ensembl:ENSMUSG00000023913 AllianceGenome:MGI:1351327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAF-AH
    Summary
    Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasm and extracellular space. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 43.2), frontal lobe adult (RPKM 30.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B3; 17 19.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43879009..43923093)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43567994..43612202)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha Neighboring gene ankyrin repeat domain 66 Neighboring gene STARR-seq mESC enhancer starr_42596 Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene STARR-seq mESC enhancer starr_42598 Neighboring gene tudor domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43782177-43782395 Neighboring gene solute carrier family 25, member 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway. Yao J, et al. PeerJ, 2023. PMID 37397012, Free PMC Article
    2. Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis. Wang J, et al. Pharmacol Res, 2022 Aug. PMID 35662628
    3. Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. He S, et al. Circ Heart Fail, 2015 Sep. PMID 26232205, Free PMC Article
    4. The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Jiang Z, et al. Respir Res, 2012 Nov 12. PMID 23140447, Free PMC Article
    5. Identification and regulation of the platelet-activating factor acetylhydrolase activity in the mouse uterus in early pregnancy. Chami O, et al. Reprod Fertil Dev, 2001. PMID 11833932

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
      Title: Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
    2. Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis.
      Title: Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis.
    3. Caloric restriction in humans reveals immunometabolic regulators of health span.
      Title: Caloric restriction in humans reveals immunometabolic regulators of health span.
    4. Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
      Title: Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
    5. Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.
      Title: Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.
    6. PLA2G7 silencing can improve the myocardial fibrosis in mice with coronary atherosclerosis, and PLA2G7 is expected to be a potential target for coronary atherosclerosis
      Title: Regulation of lipoprotein-associated phospholipase A2 silencing on myocardial fibrosis in mice with coronary atherosclerosis.
    7. Resveratrol downregulates Lp-PLA2 expression by inhibiting oxidative stress via SIRT1 pathway in a mouse model of chronic inflammation.
      Title: Resveratrol suppresses lipoprotein-associated phospholipase A(2) expression by reducing oxidative stress in macrophages and animal models.
    8. Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair.
      Title: Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
    9. Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
      Title: Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditions.
    10. SAA up-regulates Lp-PLA2 production significantly via a FPRL1/MAPKs./PPAR-gamma signaling pathway.
      Title: Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma lipoprotein particle oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activating factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activating factor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase
    Names
    1-alkyl-2-acetylglycerophosphocholine esterase
    2-acetyl-1-alkylglycerophosphocholine esterase
    LDL-PLA(2)
    LDL-associated phospholipase A2
    PAF 2-acylhydrolase
    PAF acetylhydrolase
    NP_001412035.1
    NP_038765.2
    XP_006524429.1
    XP_006524430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425106.1 → NP_001412035.1  platelet-activating factor acetylhydrolase precursor

      Status: VALIDATED

      Source sequence(s)
      CT010585
      UniProtKB/Swiss-Prot
      Q60963, Q8BKM3, Q921T4

    2. NM_013737.6 → NP_038765.2  platelet-activating factor acetylhydrolase precursor

      See identical proteins and their annotated locations for NP_038765.2

      Status: VALIDATED

      Source sequence(s)
      CT010585
      Consensus CDS
      CCDS28796.1
      UniProtKB/Swiss-Prot
      Q60963, Q8BKM3, Q921T4
      Related
      ENSMUSP00000024706.6, ENSMUST00000024706.12
      Conserved Domains (1) summary
      pfam03403
      Location:47 → 415
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43879009..43923093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524366.4 → XP_006524429.1  platelet-activating factor acetylhydrolase isoform X1

      See identical proteins and their annotated locations for XP_006524429.1

      UniProtKB/Swiss-Prot
      Q60963, Q8BKM3, Q921T4
      Conserved Domains (1) summary
      pfam03403
      Location:47 → 415
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    2. XM_006524367.4 → XP_006524430.1  platelet-activating factor acetylhydrolase isoform X2

      Conserved Domains (1) summary
      pfam03403
      Location:24 → 392
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60963.2 GenPept UniProtKB/Swiss-Prot:Q60963

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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