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    Pold4 polymerase (DNA-directed), delta 4 [ Mus musculus (house mouse) ]

    Gene ID: 69745, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pold4provided by MGI
    Official Full Name
    polymerase (DNA-directed), delta 4provided by MGI
    Primary source
    MGI:MGI:1916995
    See related
    Ensembl:ENSMUSG00000024854 AllianceGenome:MGI:1916995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p12; Polds; 2410012M21Rik
    Summary
    Predicted to contribute to DNA-directed DNA polymerase activity. Acts upstream of or within positive regulation of endothelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Orthologous to human POLD4 (DNA polymerase delta 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 98.4), mammary gland adult (RPKM 59.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pold4 in Genome Data Viewer
    Location:
    19 A; 19 3.93 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4281947..4283688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4231893..4233634)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4257 Neighboring gene RAD9 checkpoint clamp component A Neighboring gene RIKEN cDNA 1500032F14 gene Neighboring gene predicted gene, 30082 Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E969 Neighboring gene STARR-positive B cell enhancer ABC_E5676 Neighboring gene microRNA 6985 Neighboring gene slingshot protein phosphatase 3 Neighboring gene ankyrin repeat domain 13 family, member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pold4 is dispensable for mouse development, DNA replication and DNA repair. Gu X, et al. Gene, 2023 Jan 30. PMID 36356905
    2. Gene expression profile in fibroblast growth factor 2-transformed endothelial cells. Dell'Era P, et al. Oncogene, 2002 Apr 4. PMID 11948428
    3. FGF2-induced upregulation of DNA polymerase-delta p12 subunit in endothelial cells. Dell'Era P, et al. Oncogene, 2005 Feb 3. PMID 15608665
    4. Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage. Zhang S, et al. J Biol Chem, 2013 Feb 1. PMID 23233665, Free PMC Article
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pold4 is dispensable for mouse development, DNA replication and DNA repair.
      Title: Pold4 is dispensable for mouse development, DNA replication and DNA repair.
    2. The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways.
      Title: Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Readthrough Gm45928

    Readthrough gene: Gm45928, Included gene: Clcf1

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 4
    Names
    DNA polymerase delta smallest subunit p12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027196.4 → NP_081472.1  DNA polymerase delta subunit 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC140073, BC028520
      Consensus CDS
      CCDS29424.1
      UniProtKB/Swiss-Prot
      Q9CWP8
      UniProtKB/TrEMBL
      A0A494BBE1, Q547B4
      Related
      ENSMUSP00000025773.4, ENSMUST00000025773.5
      Conserved Domains (1) summary
      pfam04081
      Location:49 → 88
      DNA_pol_delta_4; DNA polymerase delta, subunit 4

    RNA

    1. NR_132280.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and retains a portion of intron in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC140073, BC028520, BQ561369
      Related
      ENSMUST00000235306.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4281947..4283688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWP8.1 GenPept UniProtKB/Swiss-Prot:Q9CWP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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