Plxna4 plexin A4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxna4provided by MGI
Official Full Name: plexin A4provided by MGI
Primary source: MGI:MGI:2179061
See related: Ensembl:ENSMUSG00000029765 AllianceGenome:MGI:2179061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plxa4; mKIAA1550; 9330117B14
Summary: Enables semaphorin receptor activity. Involved in axon guidance; cranial nerve structural organization; and embryonic heart tube development. Acts upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 7.4), CNS E14 (RPKM 6.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.9 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (32121478..32565127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (32144543..32588192, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination.
Title: PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination.
Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.
Title: Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.
Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
Title: Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
The same anatomical and physiological consequences occur in Ednra(+/-); Plxna4(+/-) double heterozygotes, genetically confirming functional interaction. Second-order axon guidance therefore multiplexes a smaller number of guidance cues in sequential fashion, allowing precise refinement of axon trajectories.
Title: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.
We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.
Title: Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.
These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.
Title: Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.
These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
Title: TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching.
Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD.
Title: Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.
work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding.
Title: Structural Basis for Plexin Activation and Regulation.
Results suggest that semaphoring 6a activates plexin 4a by disrupting an inhibitory plexin dimer and inducing the active dimer
Title: Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plxna4 (e-PCR), detects polymorphism
- UniSTS:472890

Plxna4 (e-PCR), detects polymorphism
- UniSTS:472891

D6Mit141.1 (e-PCR), detects polymorphism
- UniSTS:130684

MARC_9713-9714:996688545:1 (e-PCR)
- UniSTS:269978

UniSTS:10408 (e-PCR)
- UniSTS:10408

D6Mit82 (e-PCR), detects polymorphism
- UniSTS:130985

RH142388 (e-PCR)
- UniSTS:231635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branchiomotor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemorepulsion of branchiomotor axon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within facial nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facial nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glossopharyngeal nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of synapse structure	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of synapse structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within postganglionic parasympathetic fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trigeminal nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trigeminal nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vagus nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175750.3 → NP_786926.2 plexin-A4 precursor

See identical proteins and their annotated locations for NP_786926.2

Status: VALIDATED

Source sequence(s)

AB073228, AC153629, AC158678, BF456700

Consensus CDS

CCDS19985.2

UniProtKB/Swiss-Prot

E9QN64, Q5DTW8, Q80UG2, Q8BKK9

UniProtKB/TrEMBL

B9EJ29

Related

ENSMUSP00000110748.3, ENSMUST00000115096.4

Conserved Domains (8) summary

cd11274
Location:38 → 510

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

smart00423
Location:509 → 547

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1141 → 1221

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:954 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:857 → 952

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1039 → 1139

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:803 → 855

PSI; Plexin repeat

pfam08337
Location:1310 → 1863

Plexin_cytopl; Plexin cytoplasmic RasGAP domain