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    Usp35 ubiquitin specific peptidase 35 [ Mus musculus (house mouse) ]

    Gene ID: 244144, updated on 25-May-2024

    Summary

    Official Symbol
    Usp35provided by MGI
    Official Full Name
    ubiquitin specific peptidase 35provided by MGI
    Primary source
    MGI:MGI:2685339
    See related
    Ensembl:ENSMUSG00000035713 AllianceGenome:MGI:2685339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm493; Gm1088
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP35 (ubiquitin specific peptidase 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 2.8), cerebellum adult (RPKM 2.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Usp35 in Genome Data Viewer
    Location:
    7 E1; 7 53.47 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (96958610..96981502, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97309403..97332308, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) Neighboring gene STARR-positive B cell enhancer mm9_chr7:104233795-104234096 Neighboring gene STARR-seq mESC enhancer starr_19586 Neighboring gene STARR-seq mESC enhancer starr_19587 Neighboring gene growth factor receptor bound protein 2-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_19588 Neighboring gene STARR-seq mESC enhancer starr_19589 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104446044-104446345 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104480601-104480902 Neighboring gene STARR-seq mESC enhancer starr_19591 Neighboring gene potassium channel tetramerisation domain containing 21 Neighboring gene STARR-positive B cell enhancer ABC_E9293 Neighboring gene ALG8 alpha-1,3-glucosyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 35
    Names
    ubiquitin specific protease 35
    NP_001170883.1
    XP_006507886.1
    XP_006507889.1
    XP_006507892.1
    XP_011240097.1
    XP_011240099.1
    XP_011240100.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177412.2NP_001170883.1  ubiquitin carboxyl-terminal hydrolase 35

      See identical proteins and their annotated locations for NP_001170883.1

      Status: VALIDATED

      Source sequence(s)
      AC155933
      Consensus CDS
      CCDS59734.1
      UniProtKB/TrEMBL
      M0QWN7
      Related
      ENSMUSP00000137726.2, ENSMUST00000139582.9
      Conserved Domains (2) summary
      cl02553
      Location:442916
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:441915
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      96958610..96981502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507823.5XP_006507886.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

      Conserved Domains (1) summary
      cl02553
      Location:505979
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. XM_006507826.1XP_006507889.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:225699
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    3. XM_011241797.2XP_011240099.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X4

      See identical proteins and their annotated locations for XP_011240099.1

      Conserved Domains (1) summary
      cl02553
      Location:10484
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_006507829.2XP_006507892.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X4

      See identical proteins and their annotated locations for XP_006507892.1

      Conserved Domains (1) summary
      cl02553
      Location:10484
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    5. XM_011241795.4XP_011240097.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

      Conserved Domains (1) summary
      cl02553
      Location:505979
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    6. XM_011241798.4XP_011240100.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X5

    RNA

    1. XR_001785559.3 RNA Sequence

    2. XR_003946477.2 RNA Sequence

    3. XR_001785560.3 RNA Sequence

    4. XR_003946478.2 RNA Sequence

    5. XR_004934104.1 RNA Sequence