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    Ctsj cathepsin J [ Mus musculus (house mouse) ]

    Gene ID: 26898, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ctsjprovided by MGI
    Official Full Name
    cathepsin Jprovided by MGI
    Primary source
    MGI:MGI:1349426
    See related
    Ensembl:ENSMUSG00000055298 AllianceGenome:MGI:1349426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CATP; Ctsp; CatRLP
    Summary
    Predicted to enable several functions, including collagen binding activity; fibronectin binding activity; and serpin family protein binding activity. Predicted to be involved in several processes, including collagen catabolic process; proteolysis; and viral entry into host cell. Predicted to be located in Golgi apparatus; multivesicular body; and plasma membrane. Predicted to be active in extracellular space and lysosome. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in ectoplacental cone; embryo; extraembryonic component; placenta; and yolk sac. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 1014.2) See more
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    Genomic context

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    See Ctsj in Genome Data Viewer
    Location:
    13 B2; 13 32.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61147993..61153739, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61000179..61005925, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40976 Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40975 Neighboring gene cathepsin Q Neighboring gene STARR-seq mESC enhancer starr_34744 Neighboring gene zinc finger protein 930 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development of a specific inhibitor for the placental protease, cathepsin P. Hassanein M, et al. Arch Biochem Biophys, 2007 Aug 15. PMID 17531191
    2. Expression and characterization of cathepsin P. Mason RW, et al. Biochem J, 2004 Mar 1. PMID 14629193, Free PMC Article
    3. Cathepsin P, a novel protease in mouse placenta. Sol-Church K, et al. Biochem J, 1999 Oct 15. PMID 10510293, Free PMC Article
    4. Defining the substrate specificity of mouse cathepsin P. Puzer L, et al. Arch Biochem Biophys, 2005 Mar 1. PMID 15680921
    5. Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta. Nakajima A, et al. Biochem J, 2000 Aug 1. PMID 10903127, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117662

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin J
    Names
    Cat P
    cathepsin L-related protein
    cathepsin P
    catlrp-p
    gene/Cathepsin L-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356291.1 → NP_001343220.1  cathepsin J isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK005526
      Consensus CDS
      CCDS88467.1
      UniProtKB/Swiss-Prot
      Q564D9, Q91XK6, Q9R014, Q9WV51
      Related
      ENSMUSP00000153389.2, ENSMUST00000224224.2
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114 → 331
      Peptidase_C1; Papain family cysteine protease

    2. NM_012007.2 → NP_036137.1  cathepsin J isoform 2 precursor

      See identical proteins and their annotated locations for NP_036137.1

      Status: VALIDATED

      Source sequence(s)
      AF136272, AK005526, AK131661
      Consensus CDS
      CCDS49291.1
      UniProtKB/TrEMBL
      A0A0R4J0V8
      Related
      ENSMUSP00000071457.5, ENSMUST00000071526.6
      Conserved Domains (2) summary
      smart00848
      Location:29 → 86
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:113 → 330
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61147993..61153739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R014.2 GenPept UniProtKB/Swiss-Prot:Q9R014

    Gene LinkOut

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