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    Dnah2 dynein, axonemal, heavy chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 327954, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnah2provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 2provided by MGI
    Primary source
    MGI:MGI:107731
    See related
    Ensembl:ENSMUSG00000005237 AllianceGenome:MGI:107731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnhd3; Dnahc2; 4930564A01; D130094J20; 2900022L05Rik; D330014H01Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium-dependent cell motility and microtubule-based movement. Located in motile cilium. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 9.8), ovary adult (RPKM 1.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.63 cM
    Exon count:
    95
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69311635..69439934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69420807..69549108, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5241 Neighboring gene STARR-positive B cell enhancer ABC_E2996 Neighboring gene STARR-positive B cell enhancer ABC_E5242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69223376-69223485 Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene KDM1 lysine (K)-specific demethylase 6B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69231989-69232098 Neighboring gene predicted gene, 51903 Neighboring gene STARR-seq mESC enhancer starr_29847 Neighboring gene STARR-seq mESC enhancer starr_29849 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice. Hwang JY, et al. Front Cell Dev Biol, 2021. PMID 33968937, Free PMC Article
    2. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
    3. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article
    4. Dynein and kinesin regulate stress-granule and P-body dynamics. Loschi M, et al. J Cell Sci, 2009 Nov 1. PMID 19825938, Free PMC Article
    5. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of axonemal dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 2
    Names
    axonemal beta dynein heavy chain 2
    axonemal dynein heavy chain
    ciliary dynein heavy chain 2
    dynein heavy chain 2, axonemal
    dynein heavy chain domain 3
    dynein, axon, heavy chain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081330.1 → NP_001074799.1  dynein axonemal heavy chain 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596125, AL731687
      Consensus CDS
      CCDS36192.1
      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      D3Z667, Q5F222
      Related
      ENSMUSP00000104299.2, ENSMUST00000108659.2
      Conserved Domains (6) summary
      pfam03028
      Location:3759 → 4450
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:275 → 760
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1258 → 1663
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3041 → 3373
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3401 → 3617
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1800 → 2030
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001419927.1 → NP_001406856.1  dynein axonemal heavy chain 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596125, AL731687

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69311635..69439934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156769.1 → XP_036012662.1  dynein axonemal heavy chain 2 isoform X3

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (6) summary
      COG5245
      Location:1373 → 4040
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241 → 798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:1846 → 2172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2813 → 3073
      AAA_8; P-loop containing dynein motor region D4
      pfam18198
      Location:4032 → 4134
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:4140 → 4440
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_030246089.2 → XP_030101949.1  dynein axonemal heavy chain 2 isoform X2

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:1312 → 4128
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:180 → 737
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1240 → 1648
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1785 → 2111
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4143 → 4443
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_036156771.1 → XP_036012664.1  dynein axonemal heavy chain 2 isoform X5

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:1373 → 4090
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241 → 798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:1846 → 2172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2714 → 2974
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:4105 → 4405
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_036156770.1 → XP_036012663.1  dynein axonemal heavy chain 2 isoform X4

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (4) summary
      COG5245
      Location:1301 → 4117
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:169 → 726
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:1774 → 2100
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4132 → 4432
      Dynein_C; Dynein heavy chain C-terminal domain

    5. XM_006533559.3 → XP_006533622.1  dynein axonemal heavy chain 2 isoform X7

      See identical proteins and their annotated locations for XP_006533622.1

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:634 → 3450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:1 → 59
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562 → 970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1107 → 1433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3465 → 3765
      Dynein_C; Dynein heavy chain C-terminal domain

    6. XM_006533560.5 → XP_006533623.1  dynein axonemal heavy chain 2 isoform X7

      See identical proteins and their annotated locations for XP_006533623.1

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:634 → 3450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:1 → 59
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562 → 970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1107 → 1433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3465 → 3765
      Dynein_C; Dynein heavy chain C-terminal domain

    7. XM_017314611.3 → XP_017170100.1  dynein axonemal heavy chain 2 isoform X7

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:634 → 3450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:1 → 59
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562 → 970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1107 → 1433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3465 → 3765
      Dynein_C; Dynein heavy chain C-terminal domain

    8. XM_030246092.1 → XP_030101952.1  dynein axonemal heavy chain 2 isoform X9

      Conserved Domains (4) summary
      COG5245
      Location:32 → 2432
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12774
      Location:89 → 415
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:1056 → 1316
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:2447 → 2747
      Dynein_C; Dynein heavy chain C-terminal domain

    9. XM_036156772.1 → XP_036012665.1  dynein axonemal heavy chain 2 isoform X6

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (4) summary
      COG5245
      Location:1373 → 4023
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241 → 798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:1846 → 2172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2813 → 3073
      AAA_8; P-loop containing dynein motor region D4

    10. XM_036156773.1 → XP_036012666.1  dynein axonemal heavy chain 2 isoform X8

      Conserved Domains (8) summary
      pfam12777
      Location:3087 → 3229
      MT; Microtubule-binding stalk of dynein motor
      pfam17857
      Location:2669 → 2759
      AAA_lid_1; AAA+ lid domain
      pfam08385
      Location:241 → 798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1301 → 1709
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1846 → 2172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:2458 → 2638
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:2813 → 3073
      AAA_8; P-loop containing dynein motor region D4
      pfam17852
      Location:2334 → 2452
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain

    RNA

    1. XR_004936978.1 RNA Sequence

    2. XR_004936979.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177617.2: Suppressed sequence

      Description
      NM_177617.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6F1.1 GenPept UniProtKB/Swiss-Prot:P0C6F1

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