U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kcmf1 potassium channel modulatory factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74287, updated on 28-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kcmf1provided by MGI
    Official Full Name
    potassium channel modulatory factor 1provided by MGI
    Primary source
    MGI:MGI:1921537
    See related
    Ensembl:ENSMUSG00000055239 AllianceGenome:MGI:1921537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pmcf; Debt91; 1700094M07Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 46.7), ovary adult (RPKM 17.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    6 C1; 6 32.3 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72818097..72876962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72841114..72899979, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box) Neighboring gene predicted gene, 31391 Neighboring gene VISTA enhancer mm1474 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 31249 Neighboring gene STARR-seq mESC enhancer starr_16313 Neighboring gene STARR-seq mESC enhancer starr_16315 Neighboring gene STARR-seq mESC enhancer starr_16319 Neighboring gene STARR-seq mESC enhancer starr_16322 Neighboring gene STARR-seq mESC enhancer starr_16325 Neighboring gene STARR-seq mESC enhancer starr_16327 Neighboring gene STARR-seq mESC enhancer starr_16328 Neighboring gene STARR-seq mESC enhancer starr_16329 Neighboring gene nuclear encoded tRNA serine 9 (anticodon GCT) Neighboring gene thymosin beta 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Li Z, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810064
    2. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Beilke S, et al. Oncogene, 2010 Jul 15. PMID 20473331
    3. Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Sato A, et al. Neural Netw, 2008 Oct. PMID 18603407
    4. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KCMF1 mediates pro-oncogenic functions in vitro and in vivo and downregulation of KCMF1 results in the inhibition of pancreatic cancer formation in mice
      Title: The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice.
    2. Data suggest that Debt91 is an immediate early gene up-regulated during growth factor-induced branching tubulogenesis.
      Title: Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase KCMF1
    Names
    RING-type E3 ubiquitin transferase KCMF1
    clone DEBT-91
    debt-91
    differentially expressed in branching tubulogenesis 91
    potassium channel modulatory factor DEBT-91
    NP_001334160.1
    NP_062689.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347231.1 → NP_001334160.1  E3 ubiquitin-protein ligase KCMF1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC153613
      Consensus CDS
      CCDS85066.1
      UniProtKB/TrEMBL
      A0A0N4SV15
      Related
      ENSMUSP00000144910.2, ENSMUST00000204598.3
      Conserved Domains (1) summary
      pfam05605
      Location:26 → 85
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    2. NM_019715.2 → NP_062689.2  E3 ubiquitin-protein ligase KCMF1 isoform 1

      See identical proteins and their annotated locations for NP_062689.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153613, AK142436, CX734813
      Consensus CDS
      CCDS39518.1
      UniProtKB/Swiss-Prot
      Q80UY2, Q9WUM2
      Related
      ENSMUSP00000064410.9, ENSMUST00000068697.11
      Conserved Domains (3) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam14571
      Location:280 → 328
      Di19_C; Stress-induced protein Di19, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72818097..72876962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UY2.1 GenPept UniProtKB/Swiss-Prot:Q80UY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous