U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmem232 transmembrane protein 232 [ Mus musculus (house mouse) ]

    Gene ID: 381107, updated on 7-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmem232provided by MGI
    Official Full Name
    transmembrane protein 232provided by MGI
    Primary source
    MGI:MGI:2685786
    See related
    Ensembl:ENSMUSG00000045036 AllianceGenome:MGI:2685786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm940; Tes13-L; Tes13-S; E130009J12Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM232 (transmembrane protein 232). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 15.4) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmem232 in Genome Data Viewer
    Location:
    17 E1.1; 17 34.9 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65562994..65848080, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65255999..65541082, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43005 Neighboring gene predicted gene, 49865 Neighboring gene STARR-seq mESC enhancer starr_43006 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene STARR-seq mESC enhancer starr_43009 Neighboring gene STARR-seq mESC enhancer starr_43010 Neighboring gene hypoxanthine guanine phosphoribosyl transferase pseudogene Neighboring gene predicted gene 9288 Neighboring gene STARR-seq mESC enhancer starr_43012 Neighboring gene mitochondrial ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43013 Neighboring gene predicted gene, 53984 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice. He X, et al. Cells, 2023 Jun 13. PMID 37371084, Free PMC Article
    2. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-kappaB and signal transducer and activator of transcription 3 signalling pathways.
      Title: TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-κB and signal transducer and activator of transcription 3 signalling pathways.
    2. Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
      Title: Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of protein complex location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of protein complex location IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid cytoplasm removal during spermiation of flagellated sperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in outer dense fiber IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane protein 232
    Names
    testis-specific protein 13

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008973.2 → NP_001008973.2  transmembrane protein 232 isoform a

      See identical proteins and their annotated locations for NP_001008973.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AF338469, BB538070, BB618060, CAAA01027226, DV662151
      Consensus CDS
      CCDS28940.1
      UniProtKB/Swiss-Prot
      B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
      Related
      ENSMUSP00000083927.4, ENSMUST00000086722.10
      Conserved Domains (1) summary
      pfam15877
      Location:40 → 488
      TMEM232; Transmembrane protein family 232

    2. NM_001289485.1 → NP_001276414.1  transmembrane protein 232 isoform a

      See identical proteins and their annotated locations for NP_001276414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BB618060, BC150885, BX638107, CT030729
      Consensus CDS
      CCDS28940.1
      UniProtKB/Swiss-Prot
      B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
      Related
      ENSMUSP00000055652.7, ENSMUST00000062161.7
      Conserved Domains (1) summary
      pfam15877
      Location:40 → 488
      TMEM232; Transmembrane protein family 232

    3. NM_001289486.1 → NP_001276415.1  transmembrane protein 232 isoform b

      See identical proteins and their annotated locations for NP_001276415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. It encodes a shorter isoform (b), compared to isoform a.
      Source sequence(s)
      BB618060, BC172032, BX638107
      Consensus CDS
      CCDS89134.1
      UniProtKB/Swiss-Prot
      Q5K6N0
      Related
      ENSMUSP00000156833.2, ENSMUST00000233117.2
      Conserved Domains (1) summary
      pfam15877
      Location:40 → 487
      TMEM232; Transmembrane protein family 232

    4. NM_001360185.1 → NP_001347114.1  transmembrane protein 232 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC154457, AC154821, CT030729
      Consensus CDS
      CCDS89135.1
      Related
      ENSMUSP00000156513.2, ENSMUST00000233738.2
      Conserved Domains (2) summary
      pfam15877
      Location:7 → 454
      TMEM232; Transmembrane protein family 232
      cl25602
      Location:551 → 626
      DUF3552; Domain of unknown function (DUF3552)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      65562994..65848080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524493.4 → XP_006524556.1  transmembrane protein 232 isoform X2

      UniProtKB/TrEMBL
      A0A3B2W4C3
      Related
      ENSMUSP00000156859.2, ENSMUST00000233328.2
      Conserved Domains (2) summary
      pfam15877
      Location:1 → 372
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:483 → 552
      LegC3_N; LegC3 N-terminal coiled-coil domain

    2. XM_006524492.4 → XP_006524555.1  transmembrane protein 232 isoform X1

      Conserved Domains (2) summary
      pfam15877
      Location:40 → 402
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:513 → 582
      LegC3_N; LegC3 N-terminal coiled-coil domain

    3. XM_030249871.1 → XP_030105731.1  transmembrane protein 232 isoform X3

      Conserved Domains (2) summary
      pfam15877
      Location:7 → 368
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:479 → 548
      LegC3_N; LegC3 N-terminal coiled-coil domain

    RNA

    1. XR_004939547.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5K6N0.2 GenPept UniProtKB/Swiss-Prot:Q5K6N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools