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    SEPTIN10 septin 10 [ Homo sapiens (human) ]

    Gene ID: 151011, updated on 11-Apr-2024

    Summary

    Official Symbol
    SEPTIN10provided by HGNC
    Official Full Name
    septin 10provided by HGNC
    Primary source
    HGNC:HGNC:14349
    See related
    Ensembl:ENSG00000186522 MIM:611737; AllianceGenome:HGNC:14349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEPT10; Septin-10
    Summary
    This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
    Expression
    Ubiquitous expression in esophagus (RPKM 22.6), testis (RPKM 22.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109542799..109613966, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110003863..110075030, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110300376..110371543, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876451-109876952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876953-109877452 Neighboring gene Sharpr-MPRA regulatory region 14332 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109891529-109891729 Neighboring gene Sharpr-MPRA regulatory region 6940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109933325-109934314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109934315-109935303 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109964015-109964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16362 Neighboring gene microRNA 4266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110012695-110013196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110013197-110013696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110031578-110032191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110032192-110032804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110046278-110046841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110065234-110065738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110063255-110063754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110275114-110275653 Neighboring gene Sharpr-MPRA regulatory region 2497 Neighboring gene MPRA-validated peak3814 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110352345-110352845 Neighboring gene ribosomal protein L37 pseudogene 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110370433-110371342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16368 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene BMS1 pseudogene 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321496.2NP_001308425.1  septin-10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      B7Z371, E7EX45, Q59H84
      Conserved Domains (1) summary
      cd01850
      Location:6198
      CDC_Septin; CDC/Septin GTPase family
    2. NM_001321498.2NP_001308427.1  septin-10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      Consensus CDS
      CCDS82497.1
      UniProtKB/TrEMBL
      B5ME97, E7EX04
      Related
      ENSP00000349116.4, ENST00000356688.8
      Conserved Domains (2) summary
      cd01850
      Location:63331
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:44397
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    3. NM_001321499.2NP_001308428.1  septin-10 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      B7Z277, Q59H84
      Conserved Domains (1) summary
      cl21455
      Location:32164
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. NM_001321500.2NP_001308429.1  septin-10 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:40308
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21374
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    5. NM_001321501.2NP_001308430.1  septin-10 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:21289
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:2355
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    6. NM_001321502.2NP_001308431.1  septin-10 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/Swiss-Prot
      Q9P0V9
      Conserved Domains (1) summary
      cd01850
      Location:40308
      CDC_Septin; CDC/Septin GTPase family
    7. NM_001321503.2NP_001308432.1  septin-10 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q9NSH2
      Conserved Domains (1) summary
      cl38936
      Location:10141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    8. NM_001321504.2NP_001308433.1  septin-10 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84
      Conserved Domains (1) summary
      cl21455
      Location:1138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    9. NM_001321505.2NP_001308434.1  septin-10 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84, Q9H9P7
      Conserved Domains (1) summary
      cl21455
      Location:1138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    10. NM_001321506.2NP_001308435.1  septin-10 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84
      Conserved Domains (1) summary
      cl21455
      Location:10141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    11. NM_001321507.2NP_001308436.1  septin-10 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84
      Conserved Domains (1) summary
      cd01850
      Location:6198
      CDC_Septin; CDC/Septin GTPase family
    12. NM_001321508.2NP_001308437.1  septin-10 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q9NSH2
      Conserved Domains (1) summary
      cl38936
      Location:1138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    13. NM_001321509.2NP_001308438.1  septin-10 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:21289
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:2355
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    14. NM_001321510.2NP_001308439.1  septin-10 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84
      Conserved Domains (1) summary
      cl21455
      Location:32164
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    15. NM_001321511.2NP_001308440.1  septin-10 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      Q59H84
      Conserved Domains (1) summary
      cl21455
      Location:10141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    16. NM_001321512.2NP_001308441.1  septin-10 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      Consensus CDS
      CCDS82496.1
      UniProtKB/TrEMBL
      A8K7M3, E7EW69
      Related
      ENSP00000396728.1, ENST00000415095.5
      Conserved Domains (2) summary
      cd01850
      Location:63331
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:44397
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    17. NM_001321513.2NP_001308442.1  septin-10 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:54322
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:35388
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    18. NM_001321514.2NP_001308443.1  septin-10 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:48316
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:29382
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    19. NM_001321515.2NP_001308444.1  septin-10 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC011753, AC140485
      UniProtKB/TrEMBL
      A8K7M3
      Conserved Domains (2) summary
      cd01850
      Location:31299
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:12365
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    20. NM_144710.5NP_653311.1  septin-10 isoform 1

      See identical proteins and their annotated locations for NP_653311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC011753, AC140485
      Consensus CDS
      CCDS46383.1
      UniProtKB/Swiss-Prot
      B3KRQ9, Q86VP5, Q9HAH6, Q9P0V9
      UniProtKB/TrEMBL
      A8K7M3
      Related
      ENSP00000380824.2, ENST00000397712.7
      Conserved Domains (1) summary
      cd01850
      Location:63331
      CDC_Septin; CDC/Septin GTPase family
    21. NM_178584.4NP_848699.1  septin-10 isoform 2

      See identical proteins and their annotated locations for NP_848699.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. Isoform 2 is shorter than isoform 1.
      Source sequence(s)
      AC011753, AC140485
      Consensus CDS
      CCDS42726.1
      UniProtKB/TrEMBL
      A8K7M3
      Related
      ENSP00000380826.2, ENST00000397714.6
      Conserved Domains (2) summary
      cd01850
      Location:40308
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21374
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      109542799..109613966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510699.3XP_011509001.1  septin-10 isoform X3

      UniProtKB/TrEMBL
      E7EX04
      Conserved Domains (2) summary
      cd01850
      Location:40308
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21374
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    2. XM_011510702.3XP_011509004.1  septin-10 isoform X10

      Conserved Domains (1) summary
      cl21455
      Location:32164
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_011510701.4XP_011509003.1  septin-10 isoform X9

      Conserved Domains (1) summary
      cd01850
      Location:6198
      CDC_Septin; CDC/Septin GTPase family
    4. XM_011510704.4XP_011509006.1  septin-10 isoform X11

      See identical proteins and their annotated locations for XP_011509006.1

      Conserved Domains (1) summary
      cd01850
      Location:63331
      CDC_Septin; CDC/Septin GTPase family
    5. XM_006712317.3XP_006712380.1  septin-10 isoform X6

      UniProtKB/TrEMBL
      E7EX04
      Related
      ENSP00000407790.1, ENST00000437928.5
      Conserved Domains (2) summary
      cd01850
      Location:63331
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:44397
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    6. XM_011510700.3XP_011509002.1  septin-10 isoform X5

      UniProtKB/TrEMBL
      E7EX04
      Conserved Domains (2) summary
      cd01850
      Location:21289
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:227361
      DUF5401; Family of unknown function (DUF5401)
    7. XM_047443487.1XP_047299443.1  septin-10 isoform X9

    8. XM_011510698.3XP_011509000.1  septin-10 isoform X2

      UniProtKB/TrEMBL
      E7EX04
      Conserved Domains (2) summary
      cd01850
      Location:48316
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:29382
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    9. XM_047443486.1XP_047299442.1  septin-10 isoform X8

    10. XM_047443483.1XP_047299439.1  septin-10 isoform X4

    11. XM_047443488.1XP_047299444.1  septin-10 isoform X12

    12. XM_047443485.1XP_047299441.1  septin-10 isoform X7

    13. XM_011510703.3XP_011509005.1  septin-10 isoform X1

      UniProtKB/TrEMBL
      E7EX04
      Conserved Domains (2) summary
      cd01850
      Location:54322
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:35388
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    14. XM_047443484.1XP_047299440.1  septin-10 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      110003863..110075030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340716.1XP_054196691.1  septin-10 isoform X3

    2. XM_054340725.1XP_054196700.1  septin-10 isoform X10

    3. XM_054340723.1XP_054196698.1  septin-10 isoform X9

    4. XM_054340726.1XP_054196701.1  septin-10 isoform X11

    5. XM_054340720.1XP_054196695.1  septin-10 isoform X6

    6. XM_054340719.1XP_054196694.1  septin-10 isoform X6

    7. XM_054340718.1XP_054196693.1  septin-10 isoform X5

    8. XM_054340724.1XP_054196699.1  septin-10 isoform X9

    9. XM_054340715.1XP_054196690.1  septin-10 isoform X2

    10. XM_054340722.1XP_054196697.1  septin-10 isoform X8

    11. XM_054340717.1XP_054196692.1  septin-10 isoform X4

    12. XM_054340727.1XP_054196702.1  septin-10 isoform X12

    13. XM_054340721.1XP_054196696.1  septin-10 isoform X7

    14. XM_054340714.1XP_054196689.1  septin-10 isoform X1