G6pd2 glucose-6-phosphate dehydrogenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G6pd2provided by MGI
Official Full Name: glucose-6-phosphate dehydrogenase 2provided by MGI
Primary source: MGI:MGI:105977
See related: Ensembl:ENSMUSG00000089992 AllianceGenome:MGI:105977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpd2; Gpd-2; G6pdx-ps1
Summary: Predicted to enable several functions, including glucose binding activity; glucose-6-phosphate dehydrogenase activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of protein glutathionylation; and pentose-phosphate shunt, oxidative branch. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and cytosol. Is expressed in genitourinary system; nervous system; and nose. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5 C3.1; 5 31.99 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (61966186..61967820)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (61808843..61810477)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

G6pd2 (e-PCR), detects polymorphism
- UniSTS:166216

PMC85812P2 (e-PCR)
- UniSTS:273495

NoName (e-PCR)
- UniSTS:491414

UniSTS:256936 (e-PCR)
- UniSTS:256936

G6pdx (e-PCR), detects polymorphism
- UniSTS:256936

G6pd2 (e-PCR), detects polymorphism
- UniSTS:527353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables glucose binding	ISO Inferred from Sequence Orthology more info
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on CH-OH group of donors	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADPH regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein glutathionylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pentose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in ribose phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose-6-phosphate 1-dehydrogenase 2

Names: G6PD; glucose-6-phosphate dehydrogenase X-linked, pseudogene 1

NP_062341.2

EC 1.1.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019468.2 → NP_062341.2 glucose-6-phosphate 1-dehydrogenase 2

See identical proteins and their annotated locations for NP_062341.2

Status: VALIDATED

Source sequence(s)

AC114918, BC137684

Consensus CDS

CCDS19297.1

UniProtKB/Swiss-Prot

P97324, Q0VB18

UniProtKB/TrEMBL

G3UWD6

Related

ENSMUSP00000131163.2, ENSMUST00000053876.5

Conserved Domains (3) summary

TIGR00871
Location:30 → 506

zwf; glucose-6-phosphate 1-dehydrogenase

pfam00479
Location:35 → 209

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:212 → 503

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain