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    TNRC6A trinucleotide repeat containing adaptor 6A [ Homo sapiens (human) ]

    Gene ID: 27327, updated on 5-Mar-2024

    Summary

    Official Symbol
    TNRC6Aprovided by HGNC
    Official Full Name
    trinucleotide repeat containing adaptor 6Aprovided by HGNC
    Primary source
    HGNC:HGNC:11969
    See related
    Ensembl:ENSG00000090905 MIM:610739; AllianceGenome:HGNC:11969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GW1; FAME6; GW182; TNRC6; CAGH26
    Summary
    This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 11.5), endometrium (RPKM 10.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    16p12.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (24610205..24826218)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (24887133..25103177)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24621526..24837539)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24550550-24551544 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24551545-24552537 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:24586737-24587396 Neighboring gene RB binding protein 6, ubiquitin ligase Neighboring gene acyl-CoA-binding domain-containing protein 7-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10600 Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:24695075-24695665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24697561-24698060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24834133-24834633 Neighboring gene Sharpr-MPRA regulatory region 7462 Neighboring gene solute carrier family 5 member 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24917770-24918270 Neighboring gene Rho GTPase activating protein 17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24999769-25000372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25025578-25026246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25026247-25026915

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Epilepsy, familial adult myoclonic, 6
    MedGen: C4748079 OMIM: 618074 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef inhibits the sorting of GW182 into exosomes, leading to affect assembly and turnover of the miRNA-induced silencing complex (miRISC) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22043, KIAA1460, MGC75384, DKFZp666E117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    CAG repeat protein 26
    CTD-2540M10.1
    EDIE
    EMSY interactor protein
    GW182 autoantigen
    glycine-tryptophan protein of 182 kDa
    trinucleotide repeat containing 6A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330520.3 → NP_001317449.1  trinucleotide repeat-containing gene 6A protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC002565, AC008731, BU743266
      Consensus CDS
      CCDS81959.1
      UniProtKB/Swiss-Prot
      Q8NDV7
      Related
      ENSP00000326900.7, ENST00000315183.11
      Conserved Domains (4) summary
      cd12711
      Location:1731 → 1813
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1200
      Ago_hook; Argonaute hook
      pfam12938
      Location:1280 → 1411
      M_domain; M domain of GW182
      pfam16608
      Location:1455 → 1730
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. NM_001351850.2 → NP_001338779.1  trinucleotide repeat-containing gene 6A protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008731, AC010321
      Conserved Domains (4) summary
      cd12711
      Location:1740 → 1822
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1084 → 1209
      Ago_hook; Argonaute hook
      pfam12938
      Location:1265 → 1373
      M_domain; M domain of GW182
      pfam16608
      Location:1464 → 1727
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    3. NM_014494.4 → NP_055309.2  trinucleotide repeat-containing gene 6A protein isoform 1

      See identical proteins and their annotated locations for NP_055309.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC002565, AC008731, AJ492221, BE158958, BU743266
      Consensus CDS
      CCDS10624.2
      UniProtKB/Swiss-Prot
      C9JAR8, O15408, Q658L5, Q6NVB5, Q8NDV7, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268
      Related
      ENSP00000379144.3, ENST00000395799.8
      Conserved Domains (4) summary
      cd12711
      Location:1780 → 1862
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1200
      Ago_hook; Argonaute hook
      pfam12938
      Location:1295 → 1413
      M_domain; M domain of GW182
      pfam16608
      Location:1504 → 1779
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      24610205..24826218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450231.2 → XP_024305999.1  trinucleotide repeat-containing gene 6A protein isoform X1

      Conserved Domains (4) summary
      cd12711
      Location:1789 → 1871
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1084 → 1209
      Ago_hook; Argonaute hook
      pfam12938
      Location:1304 → 1422
      M_domain; M domain of GW182
      pfam16608
      Location:1513 → 1776
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. XM_017023145.3 → XP_016878634.1  trinucleotide repeat-containing gene 6A protein isoform X4

    3. XM_017023150.3 → XP_016878639.1  trinucleotide repeat-containing gene 6A protein isoform X12

    4. XM_017023144.3 → XP_016878633.1  trinucleotide repeat-containing gene 6A protein isoform X2

    5. XM_024450232.2 → XP_024306000.1  trinucleotide repeat-containing gene 6A protein isoform X8

      Conserved Domains (4) summary
      cd12711
      Location:1729 → 1811
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1084 → 1198
      Ago_hook; Argonaute hook
      pfam12938
      Location:1254 → 1362
      M_domain; M domain of GW182
      pfam16608
      Location:1453 → 1716
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    6. XM_047433918.1 → XP_047289874.1  trinucleotide repeat-containing gene 6A protein isoform X16

    7. XM_017023148.3 → XP_016878637.1  trinucleotide repeat-containing gene 6A protein isoform X7

    8. XM_024450233.2 → XP_024306001.1  trinucleotide repeat-containing gene 6A protein isoform X19

      Conserved Domains (3) summary
      cd12711
      Location:1681 → 1763
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam12938
      Location:1206 → 1314
      M_domain; M domain of GW182
      pfam16608
      Location:1405 → 1668
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    9. XM_047433924.1 → XP_047289880.1  trinucleotide repeat-containing gene 6A protein isoform X23

    10. XM_047433914.1 → XP_047289870.1  trinucleotide repeat-containing gene 6A protein isoform X11

    11. XM_047433922.1 → XP_047289878.1  trinucleotide repeat-containing gene 6A protein isoform X21

    12. XM_047433927.1 → XP_047289883.1  trinucleotide repeat-containing gene 6A protein isoform X26

    13. XM_017023152.3 → XP_016878641.1  trinucleotide repeat-containing gene 6A protein isoform X27

    14. XM_047433917.1 → XP_047289873.1  trinucleotide repeat-containing gene 6A protein isoform X15

    15. XM_047433910.1 → XP_047289866.1  trinucleotide repeat-containing gene 6A protein isoform X3

    16. XM_047433913.1 → XP_047289869.1  trinucleotide repeat-containing gene 6A protein isoform X10

    17. XM_047433920.1 → XP_047289876.1  trinucleotide repeat-containing gene 6A protein isoform X18

    18. XM_047433912.1 → XP_047289868.1  trinucleotide repeat-containing gene 6A protein isoform X9

    19. XM_047433921.1 → XP_047289877.1  trinucleotide repeat-containing gene 6A protein isoform X20

    20. XM_047433926.1 → XP_047289882.1  trinucleotide repeat-containing gene 6A protein isoform X25

    21. XM_047433916.1 → XP_047289872.1  trinucleotide repeat-containing gene 6A protein isoform X14

    22. XM_047433923.1 → XP_047289879.1  trinucleotide repeat-containing gene 6A protein isoform X22

    23. XM_047433930.1 → XP_047289886.1  trinucleotide repeat-containing gene 6A protein isoform X30

    24. XM_047433931.1 → XP_047289887.1  trinucleotide repeat-containing gene 6A protein isoform X31

    25. XM_047433935.1 → XP_047289891.1  trinucleotide repeat-containing gene 6A protein isoform X35

    26. XM_047433936.1 → XP_047289892.1  trinucleotide repeat-containing gene 6A protein isoform X36

    27. XM_047433943.1 → XP_047289899.1  trinucleotide repeat-containing gene 6A protein isoform X40

    28. XM_047433941.1 → XP_047289897.1  trinucleotide repeat-containing gene 6A protein isoform X38

    29. XM_017023153.2 → XP_016878642.1  trinucleotide repeat-containing gene 6A protein isoform X37

      UniProtKB/Swiss-Prot
      Q8NDV7
      Conserved Domains (4) summary
      cd12711
      Location:1527 → 1609
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:816 → 947
      Ago_hook; Argonaute hook
      pfam12938
      Location:1042 → 1160
      M_domain; M domain of GW182
      pfam16608
      Location:1251 → 1526
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    30. XM_047433939.1 → XP_047289895.1  trinucleotide repeat-containing gene 6A protein isoform X37

    31. XM_017023146.2 → XP_016878635.1  trinucleotide repeat-containing gene 6A protein isoform X5

    32. XM_047433915.1 → XP_047289871.1  trinucleotide repeat-containing gene 6A protein isoform X13

    33. XM_047433925.1 → XP_047289881.1  trinucleotide repeat-containing gene 6A protein isoform X24

    34. XM_047433929.1 → XP_047289885.1  trinucleotide repeat-containing gene 6A protein isoform X29

    35. XM_047433942.1 → XP_047289898.1  trinucleotide repeat-containing gene 6A protein isoform X39

    36. XM_047433940.1 → XP_047289896.1  trinucleotide repeat-containing gene 6A protein isoform X37

    37. XM_047433911.1 → XP_047289867.1  trinucleotide repeat-containing gene 6A protein isoform X6

    38. XM_047433919.1 → XP_047289875.1  trinucleotide repeat-containing gene 6A protein isoform X17

    39. XM_047433928.1 → XP_047289884.1  trinucleotide repeat-containing gene 6A protein isoform X28

    40. XM_047433933.1 → XP_047289889.1  trinucleotide repeat-containing gene 6A protein isoform X33

    41. XM_047433932.1 → XP_047289888.1  trinucleotide repeat-containing gene 6A protein isoform X32

    42. XM_047433934.1 → XP_047289890.1  trinucleotide repeat-containing gene 6A protein isoform X34

    43. XM_047433944.1 → XP_047289900.1  trinucleotide repeat-containing gene 6A protein isoform X41

    44. XM_047433937.1 → XP_047289893.1  trinucleotide repeat-containing gene 6A protein isoform X37

    45. XM_047433938.1 → XP_047289894.1  trinucleotide repeat-containing gene 6A protein isoform X37

    46. XM_005255257.5 → XP_005255314.1  trinucleotide repeat-containing gene 6A protein isoform X37

      See identical proteins and their annotated locations for XP_005255314.1

      UniProtKB/Swiss-Prot
      Q8NDV7
      Conserved Domains (4) summary
      cd12711
      Location:1527 → 1609
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:816 → 947
      Ago_hook; Argonaute hook
      pfam12938
      Location:1042 → 1160
      M_domain; M domain of GW182
      pfam16608
      Location:1251 → 1526
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160019.1 Reference GRCh38.p14 PATCHES

      Range
      1423..76918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      24887133..25103177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380041.1 → XP_054236016.1  trinucleotide repeat-containing gene 6A protein isoform X1

    2. XM_054380044.1 → XP_054236019.1  trinucleotide repeat-containing gene 6A protein isoform X4

    3. XM_054380051.1 → XP_054236026.1  trinucleotide repeat-containing gene 6A protein isoform X12

    4. XM_054380042.1 → XP_054236017.1  trinucleotide repeat-containing gene 6A protein isoform X2

    5. XM_054380047.1 → XP_054236022.1  trinucleotide repeat-containing gene 6A protein isoform X8

    6. XM_054380055.1 → XP_054236030.1  trinucleotide repeat-containing gene 6A protein isoform X16

    7. XM_054380046.1 → XP_054236021.1  trinucleotide repeat-containing gene 6A protein isoform X7

    8. XM_054380057.1 → XP_054236032.1  trinucleotide repeat-containing gene 6A protein isoform X19

    9. XM_054380061.1 → XP_054236036.1  trinucleotide repeat-containing gene 6A protein isoform X23

    10. XM_054380050.1 → XP_054236025.1  trinucleotide repeat-containing gene 6A protein isoform X11

    11. XM_054380059.1 → XP_054236034.1  trinucleotide repeat-containing gene 6A protein isoform X21

    12. XM_054380064.1 → XP_054236039.1  trinucleotide repeat-containing gene 6A protein isoform X26

    13. XM_054380065.1 → XP_054236040.1  trinucleotide repeat-containing gene 6A protein isoform X27

    14. XM_054380054.1 → XP_054236029.1  trinucleotide repeat-containing gene 6A protein isoform X15

    15. XM_054380043.1 → XP_054236018.1  trinucleotide repeat-containing gene 6A protein isoform X3

    16. XM_054380049.1 → XP_054236024.1  trinucleotide repeat-containing gene 6A protein isoform X10

    17. XM_054380056.1 → XP_054236031.1  trinucleotide repeat-containing gene 6A protein isoform X18

    18. XM_054380048.1 → XP_054236023.1  trinucleotide repeat-containing gene 6A protein isoform X9

    19. XM_054380058.1 → XP_054236033.1  trinucleotide repeat-containing gene 6A protein isoform X20

    20. XM_054380063.1 → XP_054236038.1  trinucleotide repeat-containing gene 6A protein isoform X25

    21. XM_054380053.1 → XP_054236028.1  trinucleotide repeat-containing gene 6A protein isoform X14

    22. XM_054380060.1 → XP_054236035.1  trinucleotide repeat-containing gene 6A protein isoform X22

    23. XM_054380067.1 → XP_054236042.1  trinucleotide repeat-containing gene 6A protein isoform X30

    24. XM_054380068.1 → XP_054236043.1  trinucleotide repeat-containing gene 6A protein isoform X31

    25. XM_054380070.1 → XP_054236045.1  trinucleotide repeat-containing gene 6A protein isoform X35

    26. XM_054380071.1 → XP_054236046.1  trinucleotide repeat-containing gene 6A protein isoform X36

    27. XM_054380079.1 → XP_054236054.1  trinucleotide repeat-containing gene 6A protein isoform X40

    28. XM_054380077.1 → XP_054236052.1  trinucleotide repeat-containing gene 6A protein isoform X38

    29. XM_054380073.1 → XP_054236048.1  trinucleotide repeat-containing gene 6A protein isoform X37

    30. XM_054380074.1 → XP_054236049.1  trinucleotide repeat-containing gene 6A protein isoform X37

    31. XM_054380045.1 → XP_054236020.1  trinucleotide repeat-containing gene 6A protein isoform X5

    32. XM_054380052.1 → XP_054236027.1  trinucleotide repeat-containing gene 6A protein isoform X13

    33. XM_054380062.1 → XP_054236037.1  trinucleotide repeat-containing gene 6A protein isoform X24

    34. XM_054380069.1 → XP_054236044.1  trinucleotide repeat-containing gene 6A protein isoform X42

    35. XM_054380066.1 → XP_054236041.1  trinucleotide repeat-containing gene 6A protein isoform X29

    36. XM_054380078.1 → XP_054236053.1  trinucleotide repeat-containing gene 6A protein isoform X39

    37. XM_054380075.1 → XP_054236050.1  trinucleotide repeat-containing gene 6A protein isoform X37

    38. XM_054380072.1 → XP_054236047.1  trinucleotide repeat-containing gene 6A protein isoform X37

    39. XM_054380076.1 → XP_054236051.1  trinucleotide repeat-containing gene 6A protein isoform X37