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    Vsig8 V-set and immunoglobulin domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 240916, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Vsig8provided by MGI
    Official Full Name
    V-set and immunoglobulin domain containing 8provided by MGI
    Primary source
    MGI:MGI:3642995
    See related
    Ensembl:ENSMUSG00000049598 AllianceGenome:MGI:3642995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG240916; A030011M19
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in metanephros; ovary; submandibular gland; testis; and trachea. Orthologous to human VSIG8 (V-set and immunoglobulin domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 20.9), testis adult (RPKM 4.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vsig8 in Genome Data Viewer
    Location:
    1 H3; 1 79.95 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172383505..172391284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172555938..172563717)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transgelin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene cilia and flagella associated protein 45 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068 Neighboring gene SLAM family member 8 Neighboring gene Fc receptor-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. Rice RH, et al. J Invest Dermatol, 2011 Sep. PMID 21614015, Free PMC Article
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VSIG8 is found in the hair follicle, nails and oral cavity.
      Title: Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-set and immunoglobulin domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177723.4 → NP_808391.2  V-set and immunoglobulin domain-containing protein 8 precursor

      See identical proteins and their annotated locations for NP_808391.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AK037228, AW986342, BC064106
      Consensus CDS
      CCDS15516.1
      UniProtKB/Swiss-Prot
      Q6P3A4
      Related
      ENSMUSP00000058008.4, ENSMUST00000061835.10
      Conserved Domains (2) summary
      cd00096
      Location:29 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:28 → 129
      Ig; Immunoglobulin domain

    RNA

    1. NR_027644.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. The longest ORF of the resulting transcript would encode a protein with a shorter N-terminus compared to the protein encoded by variant 1. However, there is an upstream ORF (uORF) in variant 2 that overlaps the translational start site of the longest ORF. The uORF has a strong Kozak signal and presumably prevents translation of the long ORF. Therefore, the transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is likely not protein-coding.
      Source sequence(s)
      AW986342, BC064106
      Related
      ENSMUST00000177086.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172383505..172391284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496856.5 → XP_006496919.1  V-set and immunoglobulin domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:160 → 250
      Ig; Immunoglobulin domain
      pfam07686
      Location:33 → 139
      V-set; Immunoglobulin V-set domain

    2. XM_006496857.5 → XP_006496920.1  V-set and immunoglobulin domain-containing protein 8 isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:148 → 238
      Ig; Immunoglobulin domain
      pfam07686
      Location:21 → 127
      V-set; Immunoglobulin V-set domain

    3. XM_006496858.4 → XP_006496921.1  V-set and immunoglobulin domain-containing protein 8 isoform X3

      Conserved Domains (2) summary
      cd00096
      Location:131 → 221
      Ig; Immunoglobulin domain
      pfam07686
      Location:4 → 110
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3A4.2 GenPept UniProtKB/Swiss-Prot:Q6P3A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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