Akr1b1 aldo-keto reductase family 1 member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1b1provided by MGI
Official Full Name: aldo-keto reductase family 1 member Bprovided by MGI
Primary source: MGI:MGI:1353494
See related: Ensembl:ENSMUSG00000001642 AllianceGenome:MGI:1353494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b3; Aldor1
Summary: Enables alditol:NADP+ 1-oxidoreductase activity. Acts upstream of or within several processes, including epithelial cell maturation; metanephric collecting duct development; and renal water homeostasis. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 290.1), heart adult (RPKM 93.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 14.87 cM; 6 B1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34280865..34294424, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34303930..34317489, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High incidence of sebaceous gland inflammation in aldose reductase-deficient mice.
Title: High incidence of sebaceous gland inflammation in aldose reductase-deficient mice.
Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis.
Title: Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis.
Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis.
Title: Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis.
Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue.
Title: Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue.
Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
Title: Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
AR deficiency accentuates the pathological effects of transverse aortic constriction.
Title: Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice.
modulation of macrophage metabolism by inhibition of AR might represent a novel strategy to modulate host defense responses and to modify metabolism to promote macrophage hypertrophy and phagocytosis under inflammatory conditions
Title: Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.
Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Title: Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice.
AR overexpression elevates retinal microglia activation in retina.
Title: Aldose reductase mediates retinal microglia activation.
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53.
Title: Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glucuronate reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables allyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables glyceraldehyde oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to methylglyoxal	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner medullary collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephric collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sorbitol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in Schwann cell microvillus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mast cell granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member B1

Names: aldehyde reductase 1; aldo-keto reductase family 1 member B3; aldose reductase

NP_033788.3

EC 1.1.1.21

EC 1.1.1.300

EC 1.1.1.372

EC 1.1.1.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009658.3 → NP_033788.3 aldo-keto reductase family 1 member B1

See identical proteins and their annotated locations for NP_033788.3

Status: VALIDATED

Source sequence(s)

AK164682, AV301527, BY749711

Consensus CDS

CCDS19990.1

UniProtKB/Swiss-Prot

O70130, P45376, Q99KC9

UniProtKB/TrEMBL

Q3UDY1, Q5U415

Related

ENSMUSP00000100045.5, ENSMUST00000102980.11

Conserved Domains (2) summary

COG0656
Location:1 → 297

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:8 → 289

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]