Ccr5 C-C motif chemokine receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr5provided by MGI
Official Full Name: C-C motif chemokine receptor 5provided by MGI
Primary source: MGI:MGI:107182
See related: Ensembl:ENSMUSG00000079227 AllianceGenome:MGI:107182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AM4-7; CD195; Cmkbr5
Summary: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.2), mammary gland adult (RPKM 2.1) and 27 other tissues See more
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Genomic context

Location:: 9 F4; 9 75.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123921557..123934153)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (124121543..124127183)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.
Title: Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.
Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle.
Title: Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle.
CCR5 regulates Abeta1-42-induced learning and memory deficits in mice.
Title: CCR5 regulates Aβ(1-42)-induced learning and memory deficits in mice.
CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.
Title: CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.
C-C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model.
Title: C-C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model.
Centrosome clustering control in osteoclasts through CCR5-mediated signaling.
Title: Centrosome clustering control in osteoclasts through CCR5-mediated signaling.
CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.
Title: CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
Title: Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism.
Title: HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism.
CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
Title: CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.

Submit: New GeneRIF Correction See all GeneRIFs (195)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC228408P2 (e-PCR)
- UniSTS:272155

Cmkbr5 (e-PCR), detects polymorphism
- UniSTS:141359

PMC122923P1 (e-PCR)
- UniSTS:270414

PMC151896P1 (e-PCR)
- UniSTS:271190

NoName (e-PCR)
- UniSTS:224352

PMC24402P2 (e-PCR)
- UniSTS:272255

NoName (e-PCR)
- UniSTS:489121

D83648 (e-PCR)
- UniSTS:159945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 5 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 5 binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell killing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in response to cholesterol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C chemokine receptor type 5

Names: C-C CKR-5; CC-CKR-5; CCR-5; MIP-1 alpha receptor; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009917.5 → NP_034047.2 C-C chemokine receptor type 5

See identical proteins and their annotated locations for NP_034047.2

Status: VALIDATED

Source sequence(s)

AK155628, BC103574, BG091923, BY198155

Consensus CDS

CCDS40821.1

UniProtKB/Swiss-Prot

O35313, O35891, P51682, P97308, P97405, Q3ZAZ8, Q61867

UniProtKB/TrEMBL

Q3TDA4

Related

ENSMUSP00000107069.2, ENSMUST00000111442.3

Conserved Domains (1) summary

cd15184
Location:33 → 310

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

123921557..123934153

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154589.1 → XP_036010482.1 C-C chemokine receptor type 5 isoform X1

UniProtKB/Swiss-Prot

O35313, O35891, P51682, P97308, P97405, Q3ZAZ8, Q61867

UniProtKB/TrEMBL

Q3TDA4

Conserved Domains (1) summary

cd15184
Location:33 → 310

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors