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    Sec62 SEC62 homolog, preprotein translocation [ Mus musculus (house mouse) ]

    Gene ID: 69276, updated on 11-Apr-2024

    Summary

    Official Symbol
    Sec62provided by MGI
    Official Full Name
    SEC62 homolog, preprotein translocationprovided by MGI
    Primary source
    MGI:MGI:1916526
    See related
    Ensembl:ENSMUSG00000027706 AllianceGenome:MGI:1916526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HTP1; Dtrp1; Tloc1; 3100002M17Rik
    Summary
    Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within posttranslational protein targeting to endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 31.7), frontal lobe adult (RPKM 26.4) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    3 A3; 3 14.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30847025..30875412)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30792876..30821263)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590 Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene G protein-coupled receptor 160

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    translocation protein SEC62
    Names
    SEC62 homolog
    TP-1
    translocation protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357528.1NP_001344457.1  translocation protein SEC62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158135
      Conserved Domains (2) summary
      pfam03839
      Location:170304
      Sec62; Translocation protein Sec62
      cl27000
      Location:290369
      TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
    2. NM_027016.2NP_081292.1  translocation protein SEC62 isoform 2

      See identical proteins and their annotated locations for NP_081292.1

      Status: VALIDATED

      Source sequence(s)
      AC158135, DV657309
      Consensus CDS
      CCDS17286.1
      UniProtKB/Swiss-Prot
      Q6NX81, Q8BU14
      Related
      ENSMUSP00000029256.8, ENSMUST00000029256.9
      Conserved Domains (1) summary
      pfam03839
      Location:170292
      Sec62; Translocation protein Sec62

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      30847025..30875412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)