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    Ulk4 unc-51-like kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 209012, updated on 9-May-2024

    Summary

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    Official Symbol
    Ulk4provided by MGI
    Official Full Name
    unc-51-like kinase 4provided by MGI
    Primary source
    MGI:MGI:1921622
    See related
    Ensembl:ENSMUSG00000040936 AllianceGenome:MGI:1921622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730098P15; 4932415A06Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including cerebrospinal fluid circulation; cilium organization; and nervous system development. Is expressed in brain. Used to study hydrocephalus. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F4; 9 72.19 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (120793520..121115225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120964454..121286159, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:120870733-120870842 Neighboring gene predicted gene, 38502 Neighboring gene STARR-seq mESC enhancer starr_25518 Neighboring gene catenin beta 1 Neighboring gene microRNA 7090 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2313 Neighboring gene STARR-positive B cell enhancer ABC_E3868 Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene STARR-seq mESC enhancer starr_25526 Neighboring gene STARR-seq mESC enhancer starr_25527 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121280653-121280762 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121388759-121388868 Neighboring gene predicted gene, 51661 Neighboring gene predicted gene, 38661 Neighboring gene cholecystokinin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum. McCoy CJ, et al. Mol Biol Cell, 2023 Jun 1. PMID 36989043, Free PMC Article
    2. Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice. Hu L, et al. Schizophr Bull, 2022 Jun 21. PMID 35522199, Free PMC Article
    3. Ulk4 regulates GABAergic signaling and anxiety-related behavior. Liu M, et al. Transl Psychiatry, 2018 Feb 2. PMID 29391390, Free PMC Article
    4. Ulk4 Is Essential for Ciliogenesis and CSF Flow. Liu M, et al. J Neurosci, 2016 Jul 20. PMID 27445138, Free PMC Article
    5. Ulk4 deficiency leads to hypomyelination in mice. Liu M, et al. Glia, 2018 Jan. PMID 29034508

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
      Title: ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
    2. Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
      Title: Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
    3. Ulk4 +/tm1a mice exhibit anxiety-related phenotype.
      Title: Ulk4 regulates GABAergic signaling and anxiety-related behavior.
    4. This is the first evidence demonstrating that ULK4 is a crucial regulator of myelination, and ULK4 may therefore become a novel therapeutic target for hypomyelination diseases.
      Title: Ulk4 deficiency leads to hypomyelination in mice.
    5. Targeted disruption of the Ulk4 perturbed mid-neurogenesis and significantly reduced cerebral cortex in postnatal mice.
      Title: Ulk4 Regulates Neural Stem Cell Pool.
    6. This study showed that Ulk4 Is essential for Ciliogenesis and CSF Flow in mice
      Title: Ulk4 Is Essential for Ciliogenesis and CSF Flow.
    7. Congenital hydrocephalus with suppurative rhinosinusitis and otitis media in Ulk4 null mice indicative of primary ciliary dyskinesis
      Title: Congenital hydrocephalus in genetically engineered mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GABAergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebrospinal fluid circulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within layer formation in cerebral cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuroinflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuronal stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyramidal neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of tau-protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase ULK4
    NP_808257.2
    XP_006512086.1
    XP_006512087.1
    XP_006512088.1
    XP_006512089.1
    XP_011241254.1
    XP_017168752.1
    XP_030100042.1
    XP_030100043.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177589.3 → NP_808257.2  serine/threonine-protein kinase ULK4

      Status: VALIDATED

      Source sequence(s)
      AK132731, AW456669, BC065094, BM938704
      Consensus CDS
      CCDS52967.1
      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      UniProtKB/TrEMBL
      E9Q2P5
      Related
      ENSMUSP00000131342.2, ENSMUST00000171923.8
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      120793520..121115225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512024.4 → XP_006512087.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512087.1

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    2. XM_030244183.2 → XP_030100043.1  serine/threonine-protein kinase ULK4 isoform X2

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      UniProtKB/TrEMBL
      E9Q2P5
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    3. XM_030244182.1 → XP_030100042.1  serine/threonine-protein kinase ULK4 isoform X2

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      UniProtKB/TrEMBL
      E9Q2P5
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    4. XM_006512023.3 → XP_006512086.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512086.1

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    5. XM_017313263.3 → XP_017168752.1  serine/threonine-protein kinase ULK4 isoform X1

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    6. XM_006512025.5 → XP_006512088.1  serine/threonine-protein kinase ULK4 isoform X3

      UniProtKB/Swiss-Prot
      Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    7. XM_006512026.4 → XP_006512089.1  serine/threonine-protein kinase ULK4 isoform X5

    8. XM_011242952.4 → XP_011241254.1  serine/threonine-protein kinase ULK4 isoform X4

      Related
      ENSMUSP00000129214.2, ENSMUST00000171061.8
      Conserved Domains (1) summary
      cd14010
      Location:3 → 280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V129.2 GenPept UniProtKB/Swiss-Prot:Q3V129

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