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    Sec61a2 SEC61 translocon subunit alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 57743, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sec61a2provided by MGI
    Official Full Name
    SEC61 translocon subunit alpha 2provided by MGI
    Primary source
    MGI:MGI:1931071
    See related
    Ensembl:ENSMUSG00000025816 AllianceGenome:MGI:1931071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within protein transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of Sec61 translocon complex. Orthologous to human SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 18.1), CNS E18 (RPKM 14.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A1; 2 3.62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5875788..5900199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5870977..5895432, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cell division cycle 123 Neighboring gene predicted gene, 29984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene nudix hydrolase 5 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene predicted gene 13199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene predicted gene 13267 Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_03580 Neighboring gene STARR-positive B cell enhancer ABC_E2029 Neighboring gene STARR-seq mESC enhancer starr_03581 Neighboring gene UPF2 regulator of nonsense transcripts homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit alpha isoform 2; protein transport protein Sec61 subunit alpha
    Names
    Sec61 alpha
    Sec61, alpha subunit 2
    sec61 alpha-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356411.2 → NP_001343340.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL928924
      Consensus CDS
      CCDS89425.1
      UniProtKB/TrEMBL
      Q3TJD0, Q9CYJ6
      Related
      ENSMUSP00000141333.2, ENSMUST00000193792.6
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 403
      PTZ00219; Sec61 alpha subunit; Provisional

    2. NM_001421820.1 → NP_001408749.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928924

    3. NM_001421821.1 → NP_001408750.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL928924

    4. NM_001421822.1 → NP_001408751.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL928924

    5. NM_001421823.1 → NP_001408752.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL928924

    6. NM_001421824.1 → NP_001408753.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL928924

    7. NM_021305.5 → NP_067280.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 1

      See identical proteins and their annotated locations for NP_067280.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL928924
      Consensus CDS
      CCDS15668.1
      UniProtKB/Swiss-Prot
      Q9JLR1
      UniProtKB/TrEMBL
      Q3TJD0
      Related
      ENSMUSP00000100046.4, ENSMUST00000102981.10
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 469
      PTZ00219; Sec61 alpha subunit; Provisional

    RNA

    1. NR_185332.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    2. NR_185333.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    3. NR_185334.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    4. NR_185335.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    5. NR_185336.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    6. NR_185337.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928924

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      5875788..5900199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162431.1 → XP_036018324.1  protein transport protein Sec61 subunit alpha isoform X2

      Conserved Domains (1) summary
      PTZ00219
      Location:8 → 270
      PTZ00219; Sec61 alpha subunit; Provisional

    2. XM_006497517.5 → XP_006497580.1  protein transport protein Sec61 subunit alpha isoform X2

      Conserved Domains (1) summary
      PTZ00219
      Location:8 → 270
      PTZ00219; Sec61 alpha subunit; Provisional

    3. XM_030251912.2 → XP_030107772.1  protein transport protein Sec61 subunit alpha isoform X2

      Conserved Domains (1) summary
      PTZ00219
      Location:8 → 270
      PTZ00219; Sec61 alpha subunit; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLR1.3 GenPept UniProtKB/Swiss-Prot:Q9JLR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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