Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2a5provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily a, polypeptide 5provided by MGI
Primary source: MGI:MGI:88597
See related: Ensembl:ENSMUSG00000005547 AllianceGenome:MGI:88597
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Coh; CYPIIA5; Cyp15a2
Summary: Predicted to enable enzyme binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within cellular response to cadmium ion; heme metabolic process; and response to stilbenoid. Predicted to be located in cytoplasmic microtubule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13) and CYP2A6 (cytochrome P450 family 2 subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 240.7), kidney adult (RPKM 42.6) and 1 other tissue See more
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Genomic context

Location:: 7 A3; 7 15.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (26534764..26542689)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (26835339..26843264)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Title: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Nicotine enhances alcoholic fatty liver by action of CYP2A5, which promotes generation of reactive oxygen species during metabolism of nicotine.
Title: Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.
Ppar-gamma was a transcriptional activator of Cyp2a5.
Title: Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.
Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype
Title: Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARalpha-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.
Title: Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference
Title: The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
Results suggest that cytochrome P450 2A5 protects against ethanol-induced oxidative liver injury.
Title: Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.
results suggested that NO plays a role in the reversal of the low-dose LPS-induced depression of CYP2A5 observed when mice were challenged with higher doses of LPS
Title: Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
Study demonstrated that in mouse livers,the redox-sensitive transcription factor Nrf2 is involved in the gene expression of Cyp2b10 and Cyp2a5.
Title: Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.
Results suggest that expression of CYP2A5 is modulated by Nrf2 in response to a high fat diet.
Title: Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

13.MMHAP21FLE1.seq (e-PCR)
- UniSTS:123159

AI893559 (e-PCR)
- UniSTS:179536

D17973 (e-PCR)
- UniSTS:124754

Cyp2a4 (e-PCR), detects polymorphism
- UniSTS:462989

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables coumarin 7-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in coumarin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2A5

Names: coumarin 7-hydroxylase; cytochrome P450, 2a5; cytochrome P450-15-COH; cytochrome P450-IIA3.2

NP_031838.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.